Special Section on Cardiovascular Photonics

In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque

[+] Author Affiliations
Jason T. Motz

Massachusetts General Hospital, Harvard Medical School, Wellman Center for Photomedicine, Boston, Massachusetts 02114 jmotz@partners.org

Maryann Fitzmaurice

University Hospitals of Cleveland, Cleveland, Ohio and Case Western Reserve University, Cleveland, Ohio 44106

Arnold Miller

Metro West Medical Center, Natick, Massachusetts 01760

Saumil J. Gandhi, Abigail S. Haka, Luis H. Galindo, Ramachandra R. Dasari, John R. Kramer, Michael S. Feld

Massachusetts Institute of Technology, George R. Harrison Spectroscopy Laboratory, Cambridge, Massachusetts 02139

J. Biomed. Opt. 11(2), 021003 (April 05, 2006). doi:10.1117/1.2190967
History: Received July 11, 2005; Revised October 14, 2005; Accepted October 17, 2005; Published April 05, 2006
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The rupture of vulnerable atherosclerotic plaque accounts for the majority of clinically significant acute cardiovascular events. Because stability of these culprit lesions is directly related to chemical and morphological composition, Raman spectroscopy may be a useful technique for their study. Recent developments in optical fiber probe technology have allowed for the real-time in vivo Raman spectroscopic characterization of human atherosclerotic plaque demonstrated in this work. We spectroscopically examine 74 sites during carotid endarterectomy and femoral artery bypass surgeries. Of these, 34 are surgically biopsied and examined histologically. Excellent signal-to-noise ratio spectra are obtained in only 1s and fit with an established model, demonstrating accurate tissue characterization. We also report the first evidence that Raman spectroscopy has the potential to identify vulnerable plaque, achieving a sensitivity and specificity of 79 and 85%, respectively. These initial findings indicate that Raman spectroscopy has the potential to be a clinically relevant diagnostic tool for studying cardiovascular disease.

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© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Jason T. Motz ; Maryann Fitzmaurice ; Arnold Miller ; Saumil J. Gandhi ; Abigail S. Haka, et al.
"In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque", J. Biomed. Opt. 11(2), 021003 (April 05, 2006). ; http://dx.doi.org/10.1117/1.2190967


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