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Research Papers

Simple device for the direct visualization of oral-cavity tissue fluorescence

[+] Author Affiliations
Pierre M. Lane

British Columbia Cancer Research Center, Cancer Imaging Department, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada

Terence Gilhuly, Peter Whitehead

LED Medical Diagnostics Inc., #201-15047 Marine Drive, White Rock, British Columbia V4B 1C5, Canada

Haishan Zeng

British Columbia Cancer Research Center, Cancer Imaging Department, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada

Catherine F. Poh, Samson Ng

The University of British Columbia, Faculty of Dentistry, 2199 Westbrook Mall, Vancouver, British Columbia V6T 1Z4, Canada

P. Michele Williams

British Columbia Cancer Research Center, Oral Oncology Department, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada

Lewei Zhang

The University of British Columbia, 2199 Westbrook Mall, Vancouver, British Columbia V6T 1Z4, Canada

Miriam P. Rosin

British Columbia Cancer Research Center, Cancer Control Research Program, 675 West 10th Avenue, Vancouver, BC V5Z 1L3 and Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada

Calum E. MacAulay

British Columbia Cancer Research Center, Cancer Imaging Department, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada

J. Biomed. Opt. 11(2), 024006 (April 10, 2006). doi:10.1117/1.2193157
History: Received August 12, 2005; Revised November 13, 2005; Accepted December 16, 2005; Published April 10, 2006
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Early identification of high-risk disease could greatly reduce both mortality and morbidity due to oral cancer. We describe a simple handheld device that facilitates the direct visualization of oral-cavity fluorescence for the detection of high-risk precancerous and early cancerous lesions. Blue excitation light (400to460nm) is employed to excite green-red fluorescence from fluorophores in the oral tissues. Tissue fluorescence is viewed directly along an optical axis collinear with the axis of excitation to reduce inter- and intraoperator variability. This robust, field-of-view device enables the direct visualization of fluorescence in the context of surrounding normal tissue. Results from a pilot study of 44 patients are presented. Using histology as the gold standard, the device achieves a sensitivity of 98% and specificity of 100% when discriminating normal mucosa from severe dysplasia/carcinoma in situ (CIS) or invasive carcinoma. We envisage this device as a suitable adjunct for oral cancer screening, biopsy guidance, and margin delineation.

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© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Pierre M. Lane ; Terence Gilhuly ; Peter Whitehead ; Haishan Zeng ; Catherine F. Poh, et al.
"Simple device for the direct visualization of oral-cavity tissue fluorescence", J. Biomed. Opt. 11(2), 024006 (April 10, 2006). ; http://dx.doi.org/10.1117/1.2193157


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