Research Papers

Absorption of collagen: effects on the estimate of breast composition and related diagnostic implications

[+] Author Affiliations
Paola Taroni, Daniela Comelli, Antonio Pifferi, Alessandro Torricelli, Rinaldo Cubeddu

Politecnico di Milano, Dipartimento di Fisica, ULTRAS-CNR-INFM and IFN-CNR, Piazza Leonardo da Vinci 32, I-20133 Milano, Italy

J. Biomed. Opt. 12(1), 014021 (March 02, 2007). doi:10.1117/1.2699170
History: Received July 02, 2006; Revised September 06, 2006; Accepted September 06, 2006; Published March 02, 2007
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The absorption spectrum of collagen powder is measured between 610 and 1040nm by time-resolved transmittance spectroscopy. Absorption spectra of breast from healthy volunteers are then interpreted, adding collagen to the other absorbers previously considered (i.e., oxy- and deoxyhemoglobin, water, and lipids). A significant amount of collagen, depending on breast type, is estimated to be present. Adding collagen to the fitting procedure affects remarkably the estimated values of blood content and oxygenation. The quantification of collagen has potential implications for the assessment of breast density and cancer risk.

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© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Paola Taroni ; Daniela Comelli ; Antonio Pifferi ; Alessandro Torricelli and Rinaldo Cubeddu
"Absorption of collagen: effects on the estimate of breast composition and related diagnostic implications", J. Biomed. Opt. 12(1), 014021 (March 02, 2007). ; http://dx.doi.org/10.1117/1.2699170


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