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Research Papers

In vivo optical characterization of human prostate tissue using near-infrared time-resolved spectroscopy

[+] Author Affiliations
Tomas Svensson, Stefan Andersson-Engels

Lund University, Department of Physics, SE-221 00 Lund, Sweden

Margrét Einarsdóttír, Katarina Svanberg

Lund University Hospital, Department of Oncology, SE-221 00 Lund, Sweden

J. Biomed. Opt. 12(1), 014022 (September 05, 2006November 07, 2006November 08, 2006January 25, 2007). doi:10.1117/1.2435175
History: Received September 05, 2006; Revised November 07, 2006; Accepted November 08, 2006; Published January 25, 2007
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The development of photodynamic therapy into a modality for treatment of prostate cancer calls for reliable optical dosimetry. We employ, for the first time, interstitial time-resolved spectroscopy to determine in vivo optical properties of human prostate tissue. Nine patients are included in the study, and measurements are conducted prior to primary brachytherapy treatment of prostate cancer. Intrasubject variability is examined by measuring across three tissue volumes within each prostate. The time-resolved instrumentation proves its usefulness by producing good signal levels in all measurements. We are able to present consistent values on reduced scattering coefficients (μs), absorption coefficients (μa), and effective attenuation (μeff) at the wavelengths 660, 786, and 916nm. At 660nm, μs is found to be 9±2cm1, and μa is 0.5±0.1cm1. Derived values of μeff are in the range of 3 to 4cm1 at 660nm, a result in good agreement with previously published steady state data. Total hemoglobin concentration (THC) and oxygen saturation are spectroscopically determined using derived absorption coefficients. Derived THC values are fairly variable (215±65μM), while derived values of oxygen saturation are gathered around 75% (76±4%). Intrasubject variations in derived parameters correlate (qualitatively) with the heterogeneity exhibited in acquired ultrasound images.

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© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Tomas Svensson ; Margrét Einarsdóttír ; Katarina Svanberg and Stefan Andersson-Engels
"In vivo optical characterization of human prostate tissue using near-infrared time-resolved spectroscopy", J. Biomed. Opt. 12(1), 014022 (September 05, 2006November 07, 2006November 08, 2006January 25, 2007). ; http://dx.doi.org/10.1117/1.2435175


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