Research Papers

Detection of intramyocardial scroll waves using absorptive transillumination imaging

[+] Author Affiliations
Olivier Bernus

The State University of New York, Upstate Medical University, Department of Pharmacology, 750 East Adams Street, Syracuse, New York 13210 and Ghent University, Department of Mathematical Physics and Astronomy, Krijgslaan 281(S9), 9000 Gent, Belgium

Karthik S. Mukund, Arkady M. Pertsov

The State University of New York, Upstate Medical University, Department of Pharmacology, 750 East Adams Street, Syracuse, New York 13210

J. Biomed. Opt. 12(1), 014035 (March 01, 2007). doi:10.1117/1.2709661
History: Received March 30, 2006; Revised September 15, 2006; Accepted September 18, 2006; Published March 01, 2007
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Optical imaging using voltage-sensitive dyes has become an important tool for studying vortex-like electrical waves in the heart. Such waves, known as spiral or scroll waves, can spontaneously form in pathological ventricular myocardium, causing ventricular fibrillation and sudden death. Until recently, observations of scroll waves were limited to their surface manifestations, thus providing little information about the shape and location of their organizing center, the filament. We use computer modeling to assess the feasibility of visualizing filaments using dynamic transillumination imaging in conjunction with near-IR voltage-sensitive absorptive dyes (absorptive transillumination). We simulate transillumination signals produced by the intramural scroll waves in a realistic slab of ventricular tissue with trabeculated endocardial surface. The computations use a detailed ionic model of electrical excitation (LRd) coupled to a photon transport model for cardiac tissue. Our simulations show that dynamic absorptive transillumination data, with subsequent processing involving either amplitude maps, time-space plots, or power-of-the-dominant-frequency maps, can be used to reliably detect intramural scroll waves through the whole thickness (10mm) of the ventricular wall. Neither variations in the thickness of the myocardial wall nor noise impeded the detection of intramural filaments.

Figures in this Article
© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Olivier Bernus ; Karthik S. Mukund and Arkady M. Pertsov
"Detection of intramyocardial scroll waves using absorptive transillumination imaging", J. Biomed. Opt. 12(1), 014035 (March 01, 2007). ; http://dx.doi.org/10.1117/1.2709661


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