Research Papers

Snapshot hyperspectral imaging in ophthalmology

[+] Author Affiliations
William R. Johnson, Daniel W. Wilson, Wolfgang Fink

Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Road, Pasadena, California 91109

Mark Humayun

University of Southern California, Dohney Eye Institute, Los Angeles, California 90033

Greg Bearman

Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Road, Pasadena, California 91109

J. Biomed. Opt. 12(1), 014036 (February 02, 2007). doi:10.1117/1.2434950
History: Received September 08, 2006; Revised October 30, 2006; Accepted November 22, 2006; Published February 02, 2007
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Retinal imaging spectroscopy can provide functional maps using chromophore spectra. For example, oxygen saturation maps show ischemic areas from diabetes and venous occlusions. Obtaining retinal spatial-spectral data has been difficult due to saccades and long data acquisition times (>5s). We present a snapshot imaging spectrometer with far-reaching applicability that acquires a complete spatial-spectral image cube in 3ms from 450 to 700nm with 50 bands, eliminating motion artifacts and pixel misregistration. Current retinal spectral imaging approaches are incapable of true snapshot operation over a wide spectral range with a large number of spectral bands. Coupled to a fundus camera, the instrument returns true color retinal images for comparison to standard fundus images and for image validation while the patient is still dilated. Oxygen saturation maps were obtained with a three-wavelength algorithm: for healthy subjects arteries were 95% and veins 30 to 35% less. The instrument is now undergoing clinical trials.

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© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

William R. Johnson ; Daniel W. Wilson ; Wolfgang Fink ; Mark Humayun and Greg Bearman
"Snapshot hyperspectral imaging in ophthalmology", J. Biomed. Opt. 12(1), 014036 (February 02, 2007). ; http://dx.doi.org/10.1117/1.2434950


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