SPECIAL ISSUE HONORING BRITTON CHANCE

Preliminary evaluation of dual wavelength phased array imaging on neonatal brain function

[+] Author Affiliations
Yu Chen

Departments of Biochemistry and Biophysics, and Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania?19104

Shuoming Zhou, Chunhua Xie, Shoko Nioka

Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania?19104

Maria Delivoria-Papadopoulos, Endla Anday

Department of Pediatrics, Division of Neonatology, MCP Hahnemann University Hospital, Philadelphia, Pennsylvania?19132

Britton Chance

Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania?19104

J. Biomed. Opt. 5(2), 194-200 (Apr 01, 2000). doi:10.1117/1.429986
History: Received Aug. 31, 1999; Revised Feb. 14, 2000; Accepted Mar. 3, 2000
Text Size: A A A

Abstract

Imaging of human tissue using noninvasive techniques has been of great interest in biomedical fields. Optical imaging has attracted a lot of attention because of its portability and economy. The possibility that a highly portable, fast, safe, and affordable imaging system which could obtain interpretable images of brain function for pre- and full-term neonates in a few seconds, has been explored in this article. We have used a sensitive optical topography system, termed phased array, in which a pair of equal-amplitude and antiphase light sources are applied to generate a sharp amplitude null and phase transition plane. This two-wavelength (750 and 830 nm), frequency encoded (50 and 52 MHz) phased array imaging system can indicate the blood concentration and oxygenation changes in blood model studies and during parietal brain activation in neonates. Significant functional responses, particularly to parietal stimulation in normal and pathological states of neonatal brain, have been revealed in our study. The preliminary clinical results are presented in this article. © 2000 Society of Photo-Optical Instrumentation Engineers.

© 2000 Society of Photo-Optical Instrumentation Engineers

Topics

Brain ; Phased arrays

Citation

Yu Chen ; Shuoming Zhou ; Chunhua Xie ; Shoko Nioka ; Maria Delivoria-Papadopoulos, et al.
"Preliminary evaluation of dual wavelength phased array imaging on neonatal brain function", J. Biomed. Opt. 5(2), 194-200 (Apr 01, 2000). ; http://dx.doi.org/10.1117/1.429986


Figures

Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement


  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.