SPECIAL ISSUE HONORING BRITTON CHANCE

Three-dimensional diffuse optical mammography with ultrasound localization in a human subject

[+] Author Affiliations
M. J. Holboke

University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania?19104

Bruce J. Tromberg

University of California Irvine, Beckman Laser Institute, Irvine, California?92612

X. Li

Massachusetts Institute of Technology, Department of Electrical Engineering, Boston, Massachusetts

N. Shah, J. Fishkin

University of California Irvine, Beckman Laser Institute, Irvine, California 92612

D. Kidney

University of California Irvine Medical Center, Department of Radiology, Irvine, California 92612

J. Butler

University of California Irvine Medical Center, Department of Surgery, Irvine, California 92612

Britton Chance

University of Pennsylvania, Department of Biochemistry and Biophysics, Philadelphia, Pennsylvania?19104

Arjun G. Yodh

University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania?19104

J. Biomed. Opt. 5(2), 237-247 (Apr 01, 2000). doi:10.1117/1.429992
History: Received Oct. 30, 1999; Revised April 10, 2000; Accepted April 10, 2000
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Abstract

We describe an approach that combines clinical ultrasound and photon migration techniques to enhance the sensitivity and information content of diffuse optical tomography. Measurements were performed on a postmenopausal woman with a single 1.8×0.9 cm malignant ductal carcinoma in situ approximately 7.4 mm beneath the skin surface (UCI IRB protocol 95-563). The ultrasound-derived information about tumor geometry enabled us to segment the breast tissue into tumor and background regions. Optical data was obtained with a multifrequency, multiwavelength hand-held frequency-domain photon migration backscattering probe. The optical properties of the tumor and background were then computed using the ultrasound-derived geometrical constraints. An iterative perturbative approach, using parallel processing, provided quantitative information about scattering and absorption simultaneously with the ability to incorporate and resolve complex boundary conditions and geometries. A three to four fold increase in the tumor absorption coefficient and nearly 50% reduction in scattering coefficient relative to background was observed (λ=674, 782, 803, and 849 nm). Calculations of the mean physiological parameters reveal fourfold greater tumor total hemoglobin concentration [Hbtot] than normal breast (67 μM vs 16 μM) and tumor hemoglobin oxygen saturation (SOx) values of 63% (vs 73% and 68% in the region surrounding the tumor and the opposite normal tissue, respectively). Comparison of semi-infinite to heterogeneous models shows superior tumor/background contrast for the latter in both absorption and scattering. Sensitivity studies assessing the impact of tumor size and refractive index assumptions, as well as scan direction, demonstrate modest effects on recovered properties. © 2000 Society of Photo-Optical Instrumentation Engineers.

© 2000 Society of Photo-Optical Instrumentation Engineers

Citation

M. J. Holboke ; Bruce J. Tromberg ; X. Li ; N. Shah ; J. Fishkin, et al.
"Three-dimensional diffuse optical mammography with ultrasound localization in a human subject", J. Biomed. Opt. 5(2), 237-247 (Apr 01, 2000). ; http://dx.doi.org/10.1117/1.429992


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