CONTENTS

In vivo burn depth determination by high-speed fiber-based polarization sensitive optical coherence tomography

[+] Author Affiliations
B. Hyle Park

Beckman Laser Institute and Medical Clinic, University of California, 1002 Health Sciences Road East, Irvine, California?92612

Wellman Laboratories of Photomedicine, Massachusetts General Hospital, 50 Blossom Street BAR 724, Boston, Massachusetts?02114

Chris Saxer, Shyam M. Srinivas, J. Stuart Nelson

Beckman Laser Institute and Medical Clinic, University of California, 1002 Health Sciences Road East, Irvine, California?92612

Johannes F. de Boer

Beckman Laser Institute and Medical Clinic, University of California, 1002 Health Sciences Road East, Irvine, California?92612

and Wellman Laboratories of Photomedicine, Massachusetts General Hospital, 50 Blossom Street BAR 724, Boston, Massachusetts?02114

J. Biomed. Opt. 6(4), 474-479 (Oct 01, 2001). doi:10.1117/1.1413208
History: Received Feb. 15, 2001; Revised May 31, 2001; Accepted June 28, 2001
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We report the first application of high-speed fiber-based polarization sensitive optical coherence tomography (PS-OCT) to image burned tissue in vivo. Thermal injury denatures collagen in skin and PS-OCT can measure the reduction in collagen birefringence using depth resolved changes in the polarization state of light propagated in, and reflected from, the tissue. Stokes vectors were calculated for each point in a scan and birefringence relative to incident polarization determined using four incident polarization states. Using a high-speed fiber-based PS-OCT system on rat skin burned for varying periods of time, a correlation between birefringence and actual burn depth determined by histological analysis was established. In conclusion, PS-OCT has potential use for noninvasive assessment of burn depth. © 2001 Society of Photo-Optical Instrumentation Engineers.

© 2001 Society of Photo-Optical Instrumentation Engineers

Citation

B. Hyle Park ; Chris Saxer ; Shyam M. Srinivas ; J. Stuart Nelson and Johannes F. de Boer
"In vivo burn depth determination by high-speed fiber-based polarization sensitive optical coherence tomography", J. Biomed. Opt. 6(4), 474-479 (Oct 01, 2001). ; http://dx.doi.org/10.1117/1.1413208


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