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Quantification of optical properties of a breast tumor using random walk theory

[+] Author Affiliations
Victor Chernomordik, David W. Hattery

National Institutes of Health, National Institute of Child Health and Development, Bethesda, Maryland

Dirk Grosenick, Heidrun Wabnitz, Herbert Rinneberg

Physikalisch-Technische Bundesanstalt, Abbestrasse 2-12, D-10587 Berlin, Germany

K. Thomas Moesta, Peter M. Schlag

Humboldt University, Robert-Roessle Hospital, Charite´, Lindenberger Weg 80, D-13125 Berlin, Germany

Amir Gandjbakhche

National Institutes of Health, National Institute of Child Health and Development, Bethesda, Maryland

J. Biomed. Opt. 7(1), 80-87 (Jan 01, 2002). doi:10.1117/1.1427049
History: Received May 15, 2001; Revised July 17, 2001; Accepted July 17, 2001
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For the first time we use a random walk methodology based on time-dependent contrast functions to quantify the optical properties of breast tumors (invasive ductal carcinoma) of two patients. Previously this theoretical approach was successfully applied for analysis of embedded objects in several phantoms. Data analysis was performed on distributions of times of flight for photons transmitted through the breast which were recorded in vivo using a time-domain scanning mammograph at 670 and 785 nm. The size of the tumors, their optical properties, and those of the surrounding tissue were reconstructed at both wavelengths. The tumors showed increased absorption and scattering. From the absorption coefficients at both wavelengths blood oxygen saturation was estimated for the tumors and the surrounding tissue. © 2002 Society of Photo-Optical Instrumentation Engineers.

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© 2002 Society of Photo-Optical Instrumentation Engineers

Citation

Victor Chernomordik ; Dirk Grosenick ; K. Thomas Moesta ; Amir Gandjbakhche ; Peter M. Schlag, et al.
"Quantification of optical properties of a breast tumor using random walk theory", J. Biomed. Opt. 7(1), 80-87 (Jan 01, 2002). ; http://dx.doi.org/10.1117/1.1427049


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