Research Papers

Real-time in vivo color Doppler optical coherence tomography

[+] Author Affiliations
Andrew M. Rollins

Case Western Reserve University, Departments of Medicine and Biomedical Engineering, Cleveland, Ohio 44106-5066

Siavash Yazdanfar

Case Western Reserve University, Department of Biomedical Engineering, Cleveland, Ohio 44106-5066

Jennifer K. Barton

University of Arizona, Biomedical Engineering Program, Electrical and Computer Engineering Department, Tucson, Arizona 85721-0104

Joseph A. Izatt

Duke University, Biomedical Engineering Department, 136 Hudson Hall, Box 90281, Campus, Durham, NC 27708-0281

J. Biomed. Opt. 7(1), 123-129 (Jan 01, 2002). doi:10.1117/1.1428291
History: Received Oct. 17, 2000; Revised July 9, 2001; Accepted July 10, 2001
Text Size: A A A

Color Doppler optical coherence tomography (CDOCT) is a functional extension of optical coherence tomography (OCT) that can image flow in turbid media. We have developed a CDOCT system capable of imaging flow in real time. Doppler processing of the analog signal is accomplished in hardware in the time domain using a novel autocorrelation technique. This Doppler processing method is compatible with a high speed OCT system capable of imaging in real time. Using this system, we demonstrate cross-sectional imaging of bidirectional flow with CDOCT at four frames per second in a tissue-simulating phantom consisting of intralipid solution flowing in glass capillaries. As a demonstration of real-time imaging of blood flow in vivo we imaged pulsatible blood flow in a rat femoral artery at eight frames per second. Issues of velocity sensitivity, imaging speed, and range of velocity measurement are discussed, as well as potential applications of real-time CDOCT. © 2002 Society of Photo-Optical Instrumentation Engineers.

© 2002 Society of Photo-Optical Instrumentation Engineers

Citation

Andrew M. Rollins ; Siavash Yazdanfar ; Jennifer K. Barton and Joseph A. Izatt
"Real-time in vivo color Doppler optical coherence tomography", J. Biomed. Opt. 7(1), 123-129 (Jan 01, 2002). ; http://dx.doi.org/10.1117/1.1428291


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.