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Research Papers

Real-time in vivo color Doppler optical coherence tomography

[+] Author Affiliations
Andrew M. Rollins

Case Western Reserve University, Departments of Medicine and Biomedical Engineering, Cleveland, Ohio 44106-5066

Siavash Yazdanfar

Case Western Reserve University, Department of Biomedical Engineering, Cleveland, Ohio 44106-5066

Jennifer K. Barton

University of Arizona, Biomedical Engineering Program, Electrical and Computer Engineering Department, Tucson, Arizona 85721-0104

Joseph A. Izatt

Duke University, Biomedical Engineering Department, 136 Hudson Hall, Box 90281, Campus, Durham, NC 27708-0281

J. Biomed. Opt. 7(1), 123-129 (Jan 01, 2002). doi:10.1117/1.1428291
History: Received Oct. 17, 2000; Revised July 9, 2001; Accepted July 10, 2001
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Color Doppler optical coherence tomography (CDOCT) is a functional extension of optical coherence tomography (OCT) that can image flow in turbid media. We have developed a CDOCT system capable of imaging flow in real time. Doppler processing of the analog signal is accomplished in hardware in the time domain using a novel autocorrelation technique. This Doppler processing method is compatible with a high speed OCT system capable of imaging in real time. Using this system, we demonstrate cross-sectional imaging of bidirectional flow with CDOCT at four frames per second in a tissue-simulating phantom consisting of intralipid solution flowing in glass capillaries. As a demonstration of real-time imaging of blood flow in vivo we imaged pulsatible blood flow in a rat femoral artery at eight frames per second. Issues of velocity sensitivity, imaging speed, and range of velocity measurement are discussed, as well as potential applications of real-time CDOCT. © 2002 Society of Photo-Optical Instrumentation Engineers.

© 2002 Society of Photo-Optical Instrumentation Engineers

Citation

Andrew M. Rollins ; Siavash Yazdanfar ; Jennifer K. Barton and Joseph A. Izatt
"Real-time in vivo color Doppler optical coherence tomography", J. Biomed. Opt. 7(1), 123-129 (Jan 01, 2002). ; http://dx.doi.org/10.1117/1.1428291


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