SPECIAL SECTION ON TISSUE POLARIMETRY

Optical rotation and linear and circular depolarization rates in diffusively scattered light from chiral, racemic, and achiral turbid media

[+] Author Affiliations
Kevin C. Hadley

University of Waterloo, Department of Chemistry, Waterloo, Ontario?N2L?3G1, Canada

I. Alex Vitkin

Ontario Cancer Institute/University of Toronto, Departments of Medical Biophysics and Radiation Oncology, Toronto, Ontario?M5G?2M9, Canada

J. Biomed. Opt. 7(3), 291-299 (Jul 01, 2002). doi:10.1117/1.1483880
History: Received Mar. 8, 2002; Revised Mar. 14, 2002; Accepted Mar. 31, 2002; Online August 01, 2002
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The polarization properties of light scattered in a lateral direction from turbid media were studied. Polarization modulation and synchronous detection were used to measure, and Mueller calculus to model and derive, the degrees of surviving linear and circular polarization and the optical rotation induced by turbid samples. Polystyrene microspheres were used as scatterers in water solutions containing dissolved chiral, racemic, and achiral molecules. The preservation of circular polarization was found to exceed the linear polarization preservation for all samples examined. The optical rotation induced increased with the chiral molecule concentration only, whereas both linear and circular polarizations increased with an increase in the concentrations of chiral, racemic, and achiral molecules. This latter effect was shown to stem solely from the refractive index matching mechanism induced by the solute molecules, independent of their chiral nature. © 2002 Society of Photo-Optical Instrumentation Engineers.

© 2002 Society of Photo-Optical Instrumentation Engineers

Citation

Kevin C. Hadley and I. Alex Vitkin
"Optical rotation and linear and circular depolarization rates in diffusively scattered light from chiral, racemic, and achiral turbid media", J. Biomed. Opt. 7(3), 291-299 (Jul 01, 2002). ; http://dx.doi.org/10.1117/1.1483880


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