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Research Papers

Assessment of an in situ temporal calibration method for time-resolved optical tomography

[+] Author Affiliations
Jeremy C. Hebden, Felipe M. Gonzalez, Adam Gibson, Elizabeth M. C. Hillman, Rozarina Md. Yusof, Nick Everdell, David T. Delpy

University College London, Department of Medical Physics & Bioengineering, 11-20 Capper Street, London?WC1E?6JA, UK

Giovanni Zaccanti, Fabrizio Martelli

Universita’ degli Studi di Firenze and INFM, Dipartimento di Fisica, Via G. Sansone 1, 50019?Sesto Fiorentino, Firenze, Italy

J. Biomed. Opt. 8(1), 87-92 (Jan 01, 2003). doi:10.1117/1.1528206
History: Received Mar. 8, 2002; Revised June 24, 2002; Accepted July 15, 2002; Online January 14, 2003
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A 32-channel time-resolved optical imaging device is developed at University College London to produce functional images of the neonatal brain and the female breast. Reconstruction of images using time-resolved measurements of transmitted light requires careful calibration of the temporal characteristics of the measurement system. Since they can often vary over a period of time, it is desirable to evaluate these characteristics immediately after, or prior to, the acquisition of image data. A calibration technique is investigated that is based on the measurement of light back-reflected from the surface of the object being imaged. This is facilitated by coupling each detector channel with an individual source fiber. A Monte Carlo model is employed to investigate the influence of the optical properties of the object on the back-reflected signal. The results of simulations indicate that their influence may be small enough to be ignored in some cases, or could be largely accounted for by a small adjustment to the calibrated data. The effectiveness of the method is briefly demonstrated by imaging a solid object with tissue-equivalent optical properties. © 2003 Society of Photo-Optical Instrumentation Engineers.

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© 2003 Society of Photo-Optical Instrumentation Engineers

Citation

Jeremy C. Hebden ; Giovanni Zaccanti ; Fabrizio Martelli ; Felipe M. Gonzalez ; Adam Gibson, et al.
"Assessment of an in situ temporal calibration method for time-resolved optical tomography", J. Biomed. Opt. 8(1), 87-92 (Jan 01, 2003). ; http://dx.doi.org/10.1117/1.1528206


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