Research Papers

Temperature modulation of the visible and near infrared absorption and scattering coefficients of human skin

[+] Author Affiliations
Omar S. Khalil, Shu-jen Yeh, Michael G. Lowery, Xiaomao Wu, Charles F. Hanna, Stanislaw Kantor, Tzyy-Wen Jeng

Abbott Laboratories, Diagnostics Division, 100 Abbott Park Rd, Abbott Park, Illinois?60064 E-mail: omar.khalil@abbott.com

Johannes S. Kanger, Rene A. Bolt, Frits F. de Mul

University of Twente, Department of Applied Physics, P.O. Box 217, NL-7500?AE?Enschede, The Netherlands

J. Biomed. Opt. 8(2), 191-205 (Apr 01, 2003). doi:10.1117/1.1559997
History: Received Apr. 19, 2002; Revised Oct. 15, 2002; Accepted Oct. 30, 2002; Online April 01, 2003
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We determine temperature effect on the absorption and reduced scattering coefficients (μa and μs) of human forearm skin. Optical and thermal simulation data suggest that μa and μs are determined within a temperature-controlled depth of ≈2 mm. Cutaneous μs change linearly with temperature. Change in μa was complex and irreversible above body normal temperatures. Light penetration depth (δ) in skin increased on cooling, with considerable person-to-person variations. We attribute the effect of temperature on μs to change in refractive index mismatch, and its effect on μa to perfusion changes. The reversible temperature effect on μs was maintained during more than 90 min. contact between skin and the measuring probe, where temperature was modulated between 38 and 22 °C for multiple cycles While temperature modulated μs instantaneously and reversibly, μa exhibited slower response time and consistent drift. There was a statistically significant upward drift in μa and a mostly downward drift in μs over the contact period. The drift in temperature-induced fractional change in μs was less statistically significant than the drift in μs.Δμs values determined under temperature modulation conditions may have less nonspecific drift than μs which may have significance for noninvasive determination of analytes in human tissue. © 2003 Society of Photo-Optical Instrumentation Engineers.

© 2003 Society of Photo-Optical Instrumentation Engineers

Topics

Modulation ; Skin ; Tissues

Citation

Omar S. Khalil ; Shu-jen Yeh ; Michael G. Lowery ; Xiaomao Wu ; Charles F. Hanna, et al.
"Temperature modulation of the visible and near infrared absorption and scattering coefficients of human skin", J. Biomed. Opt. 8(2), 191-205 (Apr 01, 2003). ; http://dx.doi.org/10.1117/1.1559997


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