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Research Papers

Optoacoustic tomography using time-resolved interferometric detection of surface displacement

[+] Author Affiliations
Barry P. Payne

Massachusetts Institute of Technology, Department of Mechanical Engineering, Cambridge, Massachusetts 02139

Massachusetts General Hospital, Wellman Laboratories of Photomedicine, Boston, Massachusetts 02114

Vasan Venugopalan

University of California, Irvine, Department of Chemical Engineering and Materials Science and Laser Microbeam and Medical Program, Beckman Laser Institute, 916 Engineering Tower, Irvine, California 92697-2575 E-mail: vvenugop@uci.edu

Bora B. Mikic´

Massachusetts Institute of Technology, Department of Mechanical Engineering, Cambridge, Massachusetts 02139

Norman S. Nishioka

Massachusetts General Hospital, Wellman Laboratories of Photomedicine, Boston, Massachusetts 02114

J. Biomed. Opt. 8(2), 273-280 (Apr 01, 2003). doi:10.1117/1.1559727
History: Received Oct. 18, 2001; Revised Jun. 2, 2002; Revised Oct. 2, 2002; Accepted Oct. 7, 2002; Online April 01, 2003
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We introduce a minimally invasive technique for optoacoustic imaging of turbid media using optical interferometric detection of surface displacement produced by thermoelastic stress transients. The technique exploits endogenous or exogenous optical contrast of heterogeneous tissues and the low attenuation of stress wave propagation to localize and image subsurface absorbers in optically turbid media. We present a system that utilizes a time-resolved high-resolution interferometer capable of angstrom-level displacement resolution and nanosecond temporal resolution to detect subsurface blood vessels within model tissue phantoms and a human forearm in vivo. © 2003 Society of Photo-Optical Instrumentation Engineers.

© 2003 Society of Photo-Optical Instrumentation Engineers

Citation

Barry P. Payne ; Vasan Venugopalan ; Bora B. Mikic´ and Norman S. Nishioka
"Optoacoustic tomography using time-resolved interferometric detection of surface displacement", J. Biomed. Opt. 8(2), 273-280 (Apr 01, 2003). ; http://dx.doi.org/10.1117/1.1559727


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