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Research Papers

Spatial second-derivative image processing: an application to optical mammography to enhance the detection of breast tumors

[+] Author Affiliations
Vivian E. Pera, Erica L. Heffer

Tufts University, Bioengineering Center, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts?02155

Horst Siebold, Oliver Schu¨tz

Siemens AG, Medical Engineering, Erlangen, Germany

Sylvia Heywang-Ko¨brunner, Linda Go¨tz, Anke Heinig

Martin Luther Universitaet Halle/Wittenberg, Institut fu¨r Diagnostische Radiologie und CT, Halle, Germany

Sergio Fantini

Tufts University, Bioengineering Center, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts?02155 E-mail: sergio.fantini@tufts.edu

J. Biomed. Opt. 8(3), 517-524 (Jul 01, 2003). doi:10.1117/1.1578496
History: Received Jul. 19, 2002; Revised Dec. 12, 2002; Accepted Jan. 7, 2003; Online July 18, 2003
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We present an image-processing method that enhances the detection of regions of higher absorbance in optical mammograms. At the heart of this method lies a second-derivative operator that is commonly employed in edge-detection algorithms. The resulting images possess a high contrast, an automatic display scale, and a greater sensitivity to smaller departures from the local background absorbance. Moreover, the images are free of artifacts near the breast edge. This second-derivative method enhances the display of structural information in optical mammograms and may be used to robustly select areas of interest to be further analyzed spectrally to determine the oxygenation level of breast lesions. © 2003 Society of Photo-Optical Instrumentation Engineers.

© 2003 Society of Photo-Optical Instrumentation Engineers

Citation

Vivian E. Pera ; Erica L. Heffer ; Horst Siebold ; Oliver Schu¨tz ; Sylvia Heywang-Ko¨brunner, et al.
"Spatial second-derivative image processing: an application to optical mammography to enhance the detection of breast tumors", J. Biomed. Opt. 8(3), 517-524 (Jul 01, 2003). ; http://dx.doi.org/10.1117/1.1578496


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