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Special Section on Ophthalmic Diagnostics

Noninvasive detection of macular pigments in the human eye

[+] Author Affiliations
Werner Gellermann

University of Utah, Department of Physics, and Dixon Laser Institute, Salt Lake City, Utah E-mail: werner@physics.utah.edu

Paul S. Bernstein

University of Utah School of Medicine, Department of Ophthalmology, and Visual Sciences, Moran Eye Center, Salt Lake City, Utah

J. Biomed. Opt. 9(1), 75-85 (Jan 01, 2004). doi:10.1117/1.1628240
History: Received Apr. 8, 2003; Accepted Jul. 1, 2003; Online January 07, 2004
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There is currently strong interest in developing noninvasive technologies for the detection of macular carotenoid pigments in the human eye. These pigments, consisting of lutein and zeaxanthin, are taken up from the diet and are thought to play an important role in the prevention of age-related macular degeneration, the leading cause of blindness in the elderly in the Western world. It may be possible to prevent or delay the onset of this debilitating disease with suitable dietary intervention strategies. We review the most commonly used detection techniques based on heterochromatic flicker photometry, fundus reflectometry, and autofluorescense techniques and put them in perspective with recently developed more molecule-specific Raman detection methods. © 2004 Society of Photo-Optical Instrumentation Engineers.

© 2004 Society of Photo-Optical Instrumentation Engineers

Citation

Werner Gellermann and Paul S. Bernstein
"Noninvasive detection of macular pigments in the human eye", J. Biomed. Opt. 9(1), 75-85 (Jan 01, 2004). ; http://dx.doi.org/10.1117/1.1628240


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