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Special Section on Ophthalmic Diagnostics

New optical scheme for a polarimetric-based glucose sensor

[+] Author Affiliations
Rafat R. Ansari

Glenn Research Center, National Aeronautics and Space Administration, Mail Stop 333-1, 21000 Brookpark Road, Cleveland, Ohio 44135 E-mail: rafat.r.ansari@grc.nasa.gov

Stefan Bo¨ckle

Ohio Aerospace Institute, Glenn Research Center, National Aeronautics and Space Administration, Mail Stop 333-1, 21000 Brookpark Road, Cleveland, Ohio 44135

Luigi Rovati

University of Modena and Reggio Emilia, National Institute of Physics Matter and Department of Information Engineering, via Vignolese 905, I-41100 Modena, Italy

J. Biomed. Opt. 9(1), 103-115 (Jan 01, 2004). doi:10.1117/1.1626664
History: Received Mar. 21, 2003; Revised Jun. 26, 2003; Accepted Jun. 26, 2003; Online January 07, 2004
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A new optical scheme to detect glucose concentration in the aqueous humor of the eye is presented. The ultimate aim is to apply this technique in designing a new instrument for, routinely and frequently, noninvasively monitoring blood glucose levels in diabetic patients without contact (no index matching) between the eye and the instrument. The optical scheme exploits the Brewster reflection of circularly polarized light off of the lens of the eye. Theoretically, this reflected linearly polarized light on its way to the detector is expected to rotate its state of polarization, owing to the presence of glucose molecules in the aqueous humor of a patient’s eye. An experimental laboratory setup based on this scheme was designed and tested by measuring a range of known concentrations of glucose solutions dissolved in water. © 2004 Society of Photo-Optical Instrumentation Engineers.

© 2004 Society of Photo-Optical Instrumentation Engineers

Citation

Rafat R. Ansari ; Stefan Bo¨ckle and Luigi Rovati
"New optical scheme for a polarimetric-based glucose sensor", J. Biomed. Opt. 9(1), 103-115 (Jan 01, 2004). ; http://dx.doi.org/10.1117/1.1626664


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