Special Section on Ophthalmic Diagnostics

In vivo birefringence and thickness measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography

[+] Author Affiliations
Barry Cense

Harvard Medical School and, Wellman Laboratories of Photomedicine, Massachusetts General Hospital, 50 Blossom Street BAR 714, Boston, MA?02114 E-mail: bcense@helix.mgh.harvard.edu

Teresa C. Chen

Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA?02114

B. Hyle Park, Mark C. Pierce, Johannes F. de Boer

Harvard Medical School and, Wellman Laboratories of Photomedicine, Massachusetts General Hospital, 50 Blossom Street, Boston, MA?02114 E-mail: deboer@helix.mgh.harvard.edu

J. Biomed. Opt. 9(1), 121-125 (Jan 01, 2004). doi:10.1117/1.1627774
History: Received Mar. 5, 2003; Revised Jun. 30, 2003; Accepted Jul. 1, 2003; Online January 07, 2004
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Glaucoma causes damage of the nerve fiber layer, which may cause loss of retinal birefringence. Therefore, PS-OCT is a potentially useful technique for the early detection of glaucoma. We built a fiber-based PS-OCT setup that produces real-time images of the human retina in vivo, coregistered with retinal video images of the location of PS-OCT scans. Preliminary measurements of a healthy volunteer show that the double-pass phase retardation per unit of depth of the RNFL is not constant and varies with location, with values between 0.18 and 0.37 deg/μm. A trend in the preliminary measurements shows that the nerve fiber layer located inferior and superior to the optic nerve head is more birefringent than the thinner layer of nerve fiber tissue in the temporal and nasal regions. © 2004 Society of Photo-Optical Instrumentation Engineers.

© 2004 Society of Photo-Optical Instrumentation Engineers

Citation

Barry Cense ; Teresa C. Chen ; B. Hyle Park ; Mark C. Pierce and Johannes F. de Boer
"In vivo birefringence and thickness measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography", J. Biomed. Opt. 9(1), 121-125 (Jan 01, 2004). ; http://dx.doi.org/10.1117/1.1627774


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