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Research Papers

Determination of burn depth by polarization-sensitive optical coherence tomography

[+] Author Affiliations
Shyam M. Srinivas, Johannes F. de Boer, Hyle Park, Kourosh Keikhanzadeh, Huai-en L. Huang, Jun Zhang, Woong Qyu Jung, Zhongping Chen, J. Stuart Nelson

University of California, Irvine, Beckman Laser Institute, Department of Biomedical Engineering and Surgery, Irvine, California?92612 E-mail: snelson@laser.bli.uci.edu

J. Biomed. Opt. 9(1), 207-212 (Jan 01, 2004). doi:10.1117/1.1629680
History: Received Jun. 17, 2002; Revised Jun. 9, 2003; Accepted Jul. 1, 2003; Online January 07, 2004
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An assessment of burn depth is a key step in guiding the treatment of patients who have sustained thermal injuries. Polarization-sensitive optical coherence tomography (PS-OCT) might eventually provide the physician with a quantitative estimate of actual burn depth. Burns of various depths were induced by contacting rat skin with a brass rod preheated to 75°C for 5, 15, or 30 s. Thermal injury denatured the collagen in the skin, and PS-OCT imaged the resulting reduction of birefringence through the depth-resolved changes in the polarization state of light propagated and reflected from the sample. Stokes vectors were calculated for each point in the PS-OCT images and the reduction in the rate of phase retardation between two orthogonal polarizations of light (deg/μm) was found to show a consistent trend with burn exposure time. PS-OCT is a noninvasive technique with potential to give the physician the information needed to formulate an optimal treatment plan for burn patients. © 2004 Society of Photo-Optical Instrumentation Engineers.

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© 2004 Society of Photo-Optical Instrumentation Engineers

Citation

Shyam M. Srinivas ; Johannes F. de Boer ; Hyle Park ; Kourosh Keikhanzadeh ; Huai-en L. Huang, et al.
"Determination of burn depth by polarization-sensitive optical coherence tomography", J. Biomed. Opt. 9(1), 207-212 (Jan 01, 2004). ; http://dx.doi.org/10.1117/1.1629680


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