Research Papers

Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach

[+] Author Affiliations
JeeHyun Choi, Martin Wolf

University of Illinois at Urbana-Champaign, Laboratory for Fluorescence Dynamics, Department of Physics, 1110 W. Green St., Urbana, IL 61801-3080 E-mail: jeechoi@uiuc.edu

Vladislav Toronov

University of Illinois at Urbana-Champaign, Beckman Institute for Advanced Science and Technology, 405 North Mathews Avenue, Urbana, IL 61801-3080

Ursula Wolf, Chiara Polzonetti

University of Illinois at Urbana-Champaign, Laboratory for Fluorescence Dynamics, Department of Physics, 1110 W. Green St., Urbana, IL 61801-3080

Dennis Hueber

ISS, 1602 Newton Drive, Champaign, IL 61822

Larisa P. Safonova, Rajarsi Gupta, Antonios Michalos, William Mantulin, Enrico Gratton

University of Illinois at Urbana-Champaign, Laboratory for Fluorescence Dynamics, Department of Physics, 1110 W. Green St., Urbana, IL 61801-3080

J. Biomed. Opt. 9(1), 221-229 (Jan 01, 2004). doi:10.1117/1.1628242
History: Received Nov. 8, 2002; Revised May 1, 2003; Accepted Jul. 9, 2003; Online January 07, 2004
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The basic parameters for physiological measurements provided by near-infrared spectroscopy are the local absorption and scattering coefficients. For the adult human head, they have been difficult to measure noninvasively because of the layered structure of the head. The results of measurements of absorption and reduced scattering coefficients through the forehead on 30 adult volunteers using a multidistance frequency domain method are reported. The optode separation distance ranged from 10 to 80 mm and measurements were recorded at 758 and 830 nm. The measured absorption and reduced scattering coefficients of the forehead were used to evaluate the hemoglobin content in the scalp and brain as well as cerebral oxygen saturation. We found that cerebral oxygenation was relatively narrowly distributed within the subject group (the standard deviation was about 3% for scalp and 6% for brain, respectively), whereas hemoglobin concentrations had a relatively broader distribution. We found that as the optode distance increased, the absorption coefficients increased and the scattering coefficients decreased, retrieving the optical values of scalp and brain for shorter and longer optode distances, respectively. We present the transition curves of the absorption and reduced scattering coefficients as functions of the optode distance. In order to verify the values for each layer, a comparison between the experimental data and a prediction based on the two-layer model of the adult head was carried out. The thicknesses of scalp and skull for the two-layer model were obtained by magnetic resonance imaging of a subject’s head. The optical parameters obtained from the two-layer model agreed very well with those measured by the multidistance method. © 2004 Society of Photo-Optical Instrumentation Engineers.

© 2004 Society of Photo-Optical Instrumentation Engineers

Citation

JeeHyun Choi ; Martin Wolf ; Vladislav Toronov ; Ursula Wolf ; Chiara Polzonetti, et al.
"Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach", J. Biomed. Opt. 9(1), 221-229 (Jan 01, 2004). ; http://dx.doi.org/10.1117/1.1628242


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