Special Section on Optics of Human Skin

Computational model to evaluate port wine stain depth profiling using pulsed photothermal radiometry

[+] Author Affiliations
Bernard Choi, Boris Majaron, J. Stuart Nelson

University of California, Beckman Laser Institute, Irvine, California 92612 E-mail: bchoi@laser.bli.uci.edu

J. Biomed. Opt. 9(2), 299-307 (Mar 01, 2004). doi:10.1117/1.1646173
History: Received Mar. 19, 2003; Revised Jul. 9, 2003; Accepted Jul. 11, 2003; Online March 22, 2004
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We report on development of an optical-thermal model to evaluate the use of pulsed photothermal radiometry (PPTR) for depth profiling of port wine stain (PWS) skin. In the model, digitized histology sections of a PWS biopsy were used as the input skin geometry. Laser induced temperature profiles were reconstructed from simulated PPTR signals by applying an iterative, non-negatively constrained conjugate gradient algorithm. Accuracy of the following PWS skin characteristics extracted from the reconstructed profiles was determined: (1) average epidermal thickness (zepi), (2) maximum epidermal temperature rise (ΔTepi,max), (3) depth of PWS upper boundary (zPWS), and (4) depth of maximum PWS temperature rise (zPWS,max). Comparison of the actual and reconstructed profiles from PPTR data revealed a good match for all four PWS skin characteristics. Results of this study indicate that PPTR is a viable approach for depth profiling of PWS skin. © 2004 Society of Photo-Optical Instrumentation Engineers.

© 2004 Society of Photo-Optical Instrumentation Engineers

Citation

Bernard Choi ; Boris Majaron and J. Stuart Nelson
"Computational model to evaluate port wine stain depth profiling using pulsed photothermal radiometry", J. Biomed. Opt. 9(2), 299-307 (Mar 01, 2004). ; http://dx.doi.org/10.1117/1.1646173


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