Research Papers

Metabolic imaging of tissues by infrared fiber-optic spectroscopy: an efficient tool for medical diagnosis

[+] Author Affiliations
S. Hocde´

Universite´ de Rennes I, Laboratoire des Verres et Ce´ramiques, Avenue du Ge´ne´ral Leclerc, Campus de Beaulieu, 35042 Rennes Ce´dex, France

O. Lore´al

INSERM, U522, Re´gulations des E´quilibres Fonctionnels du Foie Normal et Pathologique, CHR Pontchaillou, 35033 Rennes Ce´dex, France

O. Sire

Universite´ de Bretagne Sud Campus de Tohannic, Laboratoire de Biologie et Chimie Mole´culaires, BP 573, 56017 Vannes Ce´dex, France

C. Boussard-Ple´del, B. Bureau

Universite´ de Rennes I, Laboratoire des Verres et Ce´ramiques, Avenue du Ge´ne´ral Leclerc, Campus de Beaulieu, 35042 Rennes Ce´dex, France

B. Turlin

INSERM, U522, Re´gulations des E´quilibres Fonctionnels du Foie Normal et Pathologique, CHR Pontchaillou, 35033 Rennes Ce´dex, France

J. Keirsse

Universite´ de Rennes I, Laboratoire des Verres et Ce´ramiques, Avenue du Ge´ne´ral Leclerc, Campus de Beaulieu, 35042 Rennes Ce´dex, France

P. Leroyer

INSERM, U522, Re´gulations des E´quilibres Fonctionnels du Foie Normal et Pathologique, CHR Pontchaillou, 35033 Rennes Ce´dex, France

J. Lucas

Universite´ de Rennes I, Laboratoire des Verres et Ce´ramiques, Avenue du Ge´ne´ral Leclerc, Campus de Beaulieu, 35042 Rennes Ce´dex, France

J. Biomed. Opt. 9(2), 404-407 (Mar 01, 2004). doi:10.1117/1.1646415
History: Received Mar. 12, 2003; Revised Jul. 25, 2003; Accepted Jul. 28, 2003; Online March 22, 2004
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Infrared fingerprints of molecules in biology contain much information on cells metabolism allowing one to distinguish between healthy and altered tissues. Here, to collect infrared signatures, we used evanescent wave spectroscopy based on an original infrared transmitting tapered glass fiber. A strict control of the fiber diameter in the tapered sensing zone allows high sensitivity and wide spectral range exploration from 800 to 3000 cm−1. Then, merely in depositing the mouse liver biopsies on the fiber, this device has enable us to differentiate between tumorous and healthy tissues. © 2004 Society of Photo-Optical Instrumentation Engineers.

© 2004 Society of Photo-Optical Instrumentation Engineers

Citation

S. Hocde´ ; O. Lore´al ; O. Sire ; C. Boussard-Ple´del ; B. Bureau, et al.
"Metabolic imaging of tissues by infrared fiber-optic spectroscopy: an efficient tool for medical diagnosis", J. Biomed. Opt. 9(2), 404-407 (Mar 01, 2004). ; http://dx.doi.org/10.1117/1.1646415


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