Research Papers

Spatial distribution of vastus lateralis blood flow and oxyhemoglobin saturation measured at the end of isometric quadriceps contraction by multichannel near-infrared spectroscopy

[+] Author Affiliations
Valentina Quaresima, Marco Ferrari

University of L’Aquila, Department of Biomedical Sciences and Technologies, 67100 L’Aquila, Italy

Maria Angela Franceschini

Harvard Medical School, Massachusetts General Hospital, NMR-Center, 13th Street Building 149, Charlestown, Massachusetts 02129,

Tufts University, Bioengineering Center, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155

Matthew L. Hoimes, Sergio Fantini

Tufts University, Bioengineering Center, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155

J. Biomed. Opt. 9(2), 413-420 (Mar 01, 2004). doi:10.1117/1.1646417
History: Received Apr. 28, 2003; Revised Jul. 31, 2003; Accepted Aug. 11, 2003; Online March 22, 2004
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Muscle blood flow (MBF) and muscle oxygen saturation (SmO2) were measured at eight locations (four proximal, four distal) over a 4×8cm2 area of the vastus lateralis at rest and immediately after isometric, maximal quadriceps contraction using multichannel, frequency-domain, near-infrared spectroscopy. A venous occlusion was applied 20 s before the end of the exercise, so that the venous-occlusion-induced increase in total hemoglobin was recorded without any delay after the end of the exercise. Therefore, we were able to investigate the relationship between the exercise-induced changes in vastus lateralis MBF and SmO2. After exercise, MBF increased significantly at each measured location. Comparing the MBF values measured at the end of exercise in the proximal and distal regions, we observed that only one proximal region had a significantly higher MBF than the corresponding distal one. The maximum desaturation measured during exercise was positively correlated with the postexercise to pre-exercise MBF ratio in both the proximal (P=0.016) and distal (P=0.0065) regions. These data confirm that frequency-domain tissue oximeters are noninvasive, powerful tools to investigate the spatial and temporal features of muscle blood flow and oxygenation, with potential applications in areas of pathophysiology. © 2004 Society of Photo-Optical Instrumentation Engineers.

© 2004 Society of Photo-Optical Instrumentation Engineers

Citation

Valentina Quaresima ; Marco Ferrari ; Maria Angela Franceschini ; Matthew L. Hoimes and Sergio Fantini
"Spatial distribution of vastus lateralis blood flow and oxyhemoglobin saturation measured at the end of isometric quadriceps contraction by multichannel near-infrared spectroscopy", J. Biomed. Opt. 9(2), 413-420 (Mar 01, 2004). ; http://dx.doi.org/10.1117/1.1646417


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