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Special Section on Biomedical Optics and Women's Health

Portable near-infrared diffusive light imager for breast cancer detection

[+] Author Affiliations
Nan Guang Chen, Minming Huang, Hongjun Xia, Daqing Piao

University of Connecticut, Department of Electrical & Computer Engineering, Storrs, Connecticut?06269

Edward Cronin

Hartford Hospital, Radiology Department, Hartford, Connecticut?06102

Quing Zhu

University of Connecticut, Department of Electrical & Computer Engineering, Storrs, Connecticut?06269

J. Biomed. Opt. 9(3), 504-510 (May 01, 2004). doi:10.1117/1.1695410
History: Received Jul. 11, 2003; Revised Jan. 19, 2004; Accepted Feb. 3, 2004; Online April 21, 2004
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We present a frequency-domain near-infrared optical tomography system designed for breast cancer detection, in conjunction with conventional ultrasound. It features fast optical switching, three-wavelength excitations, and avalanche photodiode as detectors. Laser diodes at 660, 780, and 830 nm are used as light sources and their outputs are distributed sequentially to one of nine source fibers. An equivalent 130-dB isolation between electrical signals from different source channels is achieved with the optical switches of very low crosstalk. Ten detection channels, each of which includes a silicon avalanche photodiode, detect diffusive photon density waves simultaneously. The dynamic range of an avalanche photodiode is about 20 to 30 dB higher than that of a photomultiplier tube, thus eliminating the need for multistep system gain control. The entire system is compact in size (<0.051m3) and fast in data acquisition (less than 2 sec for a complete scan). Calibration and the clinical experiment results are presented in the paper. © 2004 Society of Photo-Optical Instrumentation Engineers.

© 2004 Society of Photo-Optical Instrumentation Engineers

Citation

Nan Guang Chen ; Minming Huang ; Hongjun Xia ; Daqing Piao ; Edward Cronin, et al.
"Portable near-infrared diffusive light imager for breast cancer detection", J. Biomed. Opt. 9(3), 504-510 (May 01, 2004). ; http://dx.doi.org/10.1117/1.1695410


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