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Research Papers

Near-infrared autofluorescence imaging for detection of cancer

[+] Author Affiliations
Stavros G. Demos

Lawrence Livermore National Laboratory, PO Box 808, L-411, Livermore, California?94551

and, UC Davis Cancer Center, 4501 X Street, Sacramento, California?95817

Regina Gandour-Edwards, Rajen Ramsamooj, Ralph deVere White

UC Davis Cancer Center, 4501 X Street, Sacramento, California?95817

J. Biomed. Opt. 9(3), 587-592 (May 01, 2004). doi:10.1117/1.1688812
History: Received Nov. 5, 2002; Revised May 16, 2003; Revised Jun. 19, 2003; Accepted Aug. 22, 2003; Online April 21, 2004
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Near-infrared autofluorescence imaging of tissues under long-wavelength laser excitation in the green and red spectral region complemented by cross-polarized elastic light scattering was explored for cancer detection. Various types of normal and malignant human tissue samples were utilized in this investigation. A set of images for each tissue sample was recorded that consisted of two autofluorescence images obtained under 532- and 632.8-nm excitation and light-scattering images obtained under linearly polarized illumination at 700, 850, and 1000 nm. These images were compared with the histopathology of the tissue sample. The experimental results indicated that for various tissue types, the intensity of the autofluorescence integrated over the 700 to 1000-nm spectral region was considerably different in cancer tissues than in that of the contiguous non-neoplastic tissues. This difference provided the basis for the detection of cancer and delineation of the tumor margins. Variations on the relative intensity were observed among different tissue types and excitation wavelengths. © 2004 Society of Photo-Optical Instrumentation Engineers.

© 2004 Society of Photo-Optical Instrumentation Engineers

Citation

Stavros G. Demos ; Regina Gandour-Edwards ; Rajen Ramsamooj and Ralph deVere White
"Near-infrared autofluorescence imaging for detection of cancer", J. Biomed. Opt. 9(3), 587-592 (May 01, 2004). ; http://dx.doi.org/10.1117/1.1688812


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