Research Papers

Estimation of melanin and hemoglobin in skin tissue using multiple regression analysis aided by Monte Carlo simulation

[+] Author Affiliations
Izumi Nishidate

Muroran Institute of Technology, Division of Science for Composite Functions, 27-1 Mizumoto-cho, Muroran?050-8585, Japan

Yoshihisa Aizu, Hiromichi Mishina

Muroran Institute of Technology, Department of Mechanical Systems Engineering, 27-1 Mizumoto-cho, Muroran?050-8585, Japan E-mail: aizu@mmm.muroran-it.ac.jp

J. Biomed. Opt. 9(4), 700-710 (Jul 01, 2004). doi:10.1117/1.1756918
History: Received Jun. 16, 2003; Revised Oct. 24, 2003; Accepted Oct. 24, 2003; Online July 12, 2004
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To estimate the concentrations of melanin and blood and the oxygen saturation in human skin tissue, we propose a method using a multiple regression analysis aided by a Monte Carlo simulation for diffuse reflectance spectra from the skin tissue. By using the absorbance spectrum as a response variable and the extinction coefficients of melanin, oxygenated hemoglobin, and deoxygenated hemoglobin as predictor variables, the multiple regression analysis gives regression coefficients. The concentrations of melanin and blood are determined from the regression coefficients using conversion vectors that are estimated numerically in advance, while the oxygen saturation is obtained directly from the regression coefficients. Numerical and experimental investigations were performed for layered skin tissue models and phantoms. Measurements of human skin were also carried out to monitor variations in the melanin and blood contents and oxygenation during cuff occlusion. The results confirmed the usefulness of the proposed method. © 2004 American Institute of Physics.

© 2004 American Institute of Physics

Citation

Izumi Nishidate ; Yoshihisa Aizu and Hiromichi Mishina
"Estimation of melanin and hemoglobin in skin tissue using multiple regression analysis aided by Monte Carlo simulation", J. Biomed. Opt. 9(4), 700-710 (Jul 01, 2004). ; http://dx.doi.org/10.1117/1.1756918


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