Research Papers

Optical coherence tomography of malignancy in hamster cheek pouches

[+] Author Affiliations
Erin S. Matheny, Nevine M. Hanna, W. G. Jung, Zhongping Chen, Petra Wilder-Smith

Beckman Laser Institute, University of California, Irvine, Irvine, California?92612

Reza Mina-Araghi, Matthew Brenner

UC Irvine Medical Center, Pulmonary and Critical Care Division, Orange, California?92868

J. Biomed. Opt. 9(5), 978-981 (Sep 01, 2004). doi:10.1117/1.1783897
History: Received Dec. 4, 2003; Revised Jan. 16, 2004; Accepted Jan. 16, 2004; Online September 17, 2004
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Optical coherence tomography (OCT)/optical Doppler tomography (ODT) provides real-time in vivo high-resolution (10-μm) imaging of tissues and real-time spatially resolved blood flow in microvasculature. Hamster cheek pouches with induced dysplasia and malignancies were imaged with OCT/ODT to assess the potential for application to airway malignancy. In 22 Golden Syrian hamsters, 0.5% 9,10-dimethyl-1,2-benzanthracene induces carcinogenesis over 10 weeks in right side cheek pouches; the left side three served as controls. The cheek pouches are imaged in vivo prior to sacrifice, and in vitro after excision, using a prototype 1310-nm broadband superluminescent diode based OCT/ODT device. Images are compared to standard histopathology. OCT imaging offers good resolution of the hamster cheek pouches to depths of 1 to 3 mm and paralleled histologic images. The feasibility of high-resolution functional imaging is demonstrated in this hamster cheek pouch tumor model. ODT accurately detects vascular change associated with carcinogenesis. © 2004 Society of Photo-Optical Instrumentation Engineers.

© 2004 Society of Photo-Optical Instrumentation Engineers

Citation

Erin S. Matheny ; Nevine M. Hanna ; W. G. Jung ; Zhongping Chen ; Petra Wilder-Smith, et al.
"Optical coherence tomography of malignancy in hamster cheek pouches", J. Biomed. Opt. 9(5), 978-981 (Sep 01, 2004). ; http://dx.doi.org/10.1117/1.1783897


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