Research Papers

Measuring red blood cell flow dynamics in a glass capillary using Doppler optical coherence tomography and Doppler amplitude optical coherence tomography

[+] Author Affiliations
Julian Moger, Stephen J. Matcher, C. Peter Winlove

University of Exeter, Biomedical Physics Group, Exeter, EX4?4QL, United Kingdom

Angela Shore

Peninsular Medical School, Plymouth, PL6?8BX, United Kingdom E-mail: J.Moger@Exeter.ac.uk

J. Biomed. Opt. 9(5), 982-994 (Sep 01, 2004). doi:10.1117/1.1781163
History: Received Jun. 17, 2003; Revised Oct. 30, 2003; Accepted Feb. 16, 2004; Online September 17, 2004
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Blood, being a suspension of deformable red cells suspended in plasma, displays flow dynamics considerably more complicated than those of an ideal Newtonian fluid. Flow dynamics in blood capillaries of a few hundred micrometers in diameter are investigated using Doppler optical coherence tomography (DOCT) and Doppler amplitude optical coherence tomography (DAOCT), a novel extension of DOCT. Velocity profiles and concentration distributions of normal and rigidified in vitro red blood cell suspensions are shown to vary as functions of mean flow velocity, cell concentration, and cell rigidity. Deviation from the parabolic velocity profile expected for Pouseille flow is observed for both rigid and normal cells at low flow rates. Axial red cell migration both toward and away from the tube axis is observed for both rigid and normal cells as a function of flow velocity. Good agreement is found between our measurements, and theoretical expectations. © 2004 Society of Photo-Optical Instrumentation Engineers.

© 2004 Society of Photo-Optical Instrumentation Engineers

Citation

Julian Moger ; Stephen J. Matcher ; C. Peter Winlove and Angela Shore
"Measuring red blood cell flow dynamics in a glass capillary using Doppler optical coherence tomography and Doppler amplitude optical coherence tomography", J. Biomed. Opt. 9(5), 982-994 (Sep 01, 2004). ; http://dx.doi.org/10.1117/1.1781163


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