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Special Section on Optics in Breast Cancer

Spectroscopic time-resolved diffuse reflectance and transmittance measurements of the female breast at different interfiber distances

[+] Author Affiliations
Antonio Pifferi

Politecnico di Milano, ULTRAS-INFM, INF-CNR, Dipartimento di Fisica, P. L. da Vinci 32, I-20133?Milano, ItalyE-mail: antonio.pifferi@fisi.polimi.it

Johannes Swartling

Politecnico di Milano, Dipartimento di Fisica, P. L. da Vinci 32, I-20133?Milano, Italy

Lund University Medical Laser Centre, Department of Physics, Lund Institute of Technology, P.O. Box 118, SE-221?00?Lund, Sweden,

Ekaterine Chikoidze, Alessandro Torricelli, Paola Taroni, Andrea Bassi

Politecnico de Milano, ULTRAS-INFM, INF-CNR, Dipartimento di Fisica, P. L. da Vinci 32, I-20133?Milano, Italy

Stefan Andersson-Engels

Lund University Medical Laser Centre, Department of Physics, Lund Institute of Technology, P.O. Box 118, SE-221?00?Lund, Sweden

Rinaldo Cubeddu

Politecnico de Milano, ULTRAS-INFM, IFN-CNR, Dipartimento di Fisica, P. L. da Vinci 32, I-20133?Milano, Italy

J. Biomed. Opt. 9(6), 1143-1151 (Nov 01, 2004). doi:10.1117/1.1802171
History: Received Dec. 2, 2003; Revised Feb. 12, 2004; Accepted Feb. 13, 2004; Online November 22, 2004
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The first, to our knowledge, in-vivo broadband spectroscopic characterization of breast tissue using different interfiber distances as well as transmittance measurements is presented. Absorption and scattering properties are measured on six healthy subjects, using time-resolved diffuse spectroscopy and an inverse model based on the diffusion equation. Wavelength-tunable picosecond-pulse lasers and time-correlated single-photon counting detection are employed, enabling fully spectroscopic measurements in the range 610 to 1040 nm. Characterization of the absorption and reduced scattering coefficients of breast tissue is made with the aim of investigating individual variations, as well as variations due to different measurement geometries. Diffuse reflectance measurements at different interfiber distances (2, 3, and 4 cm) are performed, as well as measurements in transmittance mode, meaning that different sampling volumes are involved. The results show a large variation in the absorption and scattering properties depending on the subject, correlating mainly with the water versus lipid content of the breast. Intrasubject variations, due to different interfiber distances or transmittance modes, correlate with the known structures of the breast, but these variations are small compared to the subject-to-subject variation. The intrasubject variations are larger for the scattering data than the absorption data; this is consistent with different spatial localization of the measurements of these parameters, which is explained by the photon migration theory. © 2004 Society of Photo-Optical Instrumentation Engineers.

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© 2004 Society of Photo-Optical Instrumentation Engineers

Citation

Antonio Pifferi ; Johannes Swartling ; Ekaterine Chikoidze ; Stefan Andersson-Engels ; Rinaldo Cubeddu, et al.
"Spectroscopic time-resolved diffuse reflectance and transmittance measurements of the female breast at different interfiber distances", J. Biomed. Opt. 9(6), 1143-1151 (Nov 01, 2004). ; http://dx.doi.org/10.1117/1.1802171


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