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Special Section on Optics in Breast Cancer

Near-infrared imaging of the human breast: complementing hemoglobin concentration maps with oxygenation images

[+] Author Affiliations
Erica Heffer, Vivian Pera

Tufts University, Department of Biomedical Engineering, Bioengineering Center, 4 Colby Street, Medford, Massachusetts 02155 E-mail: erica.heffer@tufts.edu

Oliver Schu¨tz, Horst Siebold

Siemens AG, Medical Solutions, Erlangen, Germany

Sergio Fantini

Tufts University, Department of Biomedical Engineering, Bioengineering Center, 4 Colby Street, Medford, Massachusetts 02155 E-mail: sergio.fantini@tufts.edu

J. Biomed. Opt. 9(6), 1152-1160 (Nov 01, 2004). doi:10.1117/1.1805552
History: Received Apr. 14, 2003; Revised Nov. 14, 2003; Accepted Nov. 24, 2003; Online November 22, 2004
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We have previously reported a comparison between edge-corrected near-infrared optical mammograms and those that have undergone a further image-processing step based on a spatial second derivative. In this work, we go a step further by combining the second-derivative images from four wavelengths (690, 750, 788, and 856 nm) to obtain oxygenation-index images. While the spatial second derivative improves contrast and allows for visibility of fine structures in the images, thereby improving the sensitivity to tumor detection, additional information is needed to avoid false-positive results. The oxygenation-index images are introduced to address this issue. Oxygenation information may help discriminate benign from malignant breast lesions, thereby effectively complementing single-wavelength optical mammograms that display optically dense regions within the breast with high sensitivity. © 2004 Society of Photo-Optical Instrumentation Engineers.

© 2004 Society of Photo-Optical Instrumentation Engineers

Citation

Erica Heffer ; Vivian Pera ; Oliver Schu¨tz ; Horst Siebold and Sergio Fantini
"Near-infrared imaging of the human breast: complementing hemoglobin concentration maps with oxygenation images", J. Biomed. Opt. 9(6), 1152-1160 (Nov 01, 2004). ; http://dx.doi.org/10.1117/1.1805552


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