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Special Section on Optics in Neuroscience

Development of an optical approach for noninvasive imaging of Alzheimer’s disease pathology

[+] Author Affiliations
Jesse Skoch

Massachusetts General Hospital, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology/Alzheimer’s Disease Research Unit, 114 16th Street, Charlestown, Massachusetts 02129

Andrew Dunn

Massachusetts General Hospital, Department of Radiology, Martinos Center for Biomedical Imaging, 114 16th Street, Charlestown, Massachusetts 02129

Bradley T. Hyman, Brian J. Bacskai

Massachusetts General Hospital, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology/Alzheimer’s Disease Research Unit, 114 16th Street, Charlestown, Massachusetts 02129 E-mail: bbacskai@partners.org

J. Biomed. Opt. 10(1), 011007 (Feb. 3, 2005). doi:10.1117/1.1846075
History: Received Feb. 20, 2004; Revised Apr. 28, 2004; Accepted May 6, 2004; Feb. 3, 2005; Online February 03, 2005
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Alzheimer’s disease (AD) is characterized by the presence of aggregates of the amyloid-β (Aβ) peptide in the brain. These aggregates manifest themselves as senile plaques and cerebrovascular amyloid angiopathy (CAA). While traditional histochemical approaches can easily identify these deposits in postmortem tissue, only recently have specific ligands been developed to target Aβ in living patients using positron emission tomography (PET). Successful detection of Aβ pathology in patients will enable definitive preclinical diagnosis of AD, and enable quantitative evaluation of the efficacy of anti-Aβ therapeutics developed to treat the disease. PET scanning, however, has several disadvantages including high cost, low availability, and the requirement for radioactive tracers. We describe recent progress in the development of techniques for imaging Aβ deposits noninvasively using optical approaches. Successful development of an optical detection platform would enable inexpensive, accessible, nonradioactive detection of the Aβ deposits found in AD. © 2005 Society of Photo-Optical Instrumentation Engineers.

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© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

Jesse Skoch ; Andrew Dunn ; Bradley T. Hyman and Brian J. Bacskai
"Development of an optical approach for noninvasive imaging of Alzheimer’s disease pathology", J. Biomed. Opt. 10(1), 011007 (Feb. 3, 2005). ; http://dx.doi.org/10.1117/1.1846075


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