Research Papers

Intensity profiles of linearly polarized light backscattered from skin and tissue-like phantoms

[+] Author Affiliations
Alexander Sviridov

National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, Maryland 20892-0924

Russian Academy of Sciences, Institute for Laser and Information Technologies, Troitsk, Moscow Region, 142190, Russia

Victor Chernomordik, Moinuddin Hassan

National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, Maryland 20892-0924

Angelo Russo

National Institutes of Health, National Cancer Institute, Radiation Biology Branch, Bethesda, Maryland 20892

Alec Eidsath

National Institutes of Health, Office of Research Services, Division of Bioengineering and Physical Science, Bethesda, Maryland 20892

Paul Smith

National Institutes of Health, Office of Research Services, Division of Bioengineering and Physical Science, Bethesda, Maryland 20892

Amir H. Gandjbakhche

National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, Maryland 20892-0924

J. Biomed. Opt. 10(1), 014012 (Feb. 10, 2005). doi:10.1117/1.1854677
History: Received Feb. 6, 2004; Revised May 28, 2004; Accepted Jun. 3, 2004; Feb. 10, 2005; Online February 10, 2005
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Anisotropy of mouse and human skin is investigated in vivo using polarized videoreflectometry. An incident beam (linearly polarized, wavelength 650 nm) is focused at the sample surface. Two types of tissuelike media are used as controls to verify the technique: isotropic delrin and highly anisotropic demineralized bone with a priori knowledge of preferential orientation of collagen fibers. Equi-intensity profiles of light, backscattered from the sample, are fitted with ellipses that appear to follow the orientation of the collagen fibers. The ratio of the ellipse semiaxes is well correlated with the ratio of reduced scattering coefficients obtained from radial intensity distributions. Variation of equi-intensity profiles with distance from the incident beam is analyzed for different initial polarization states of the light and the relative orientation of polarization filters for incident and backscattered light. For the anisotropic media (demineralized bone and human and mouse skin), a qualitative difference between intensity distributions for cross- and co-polarized orientations of the polarization analyzer is observed up to a distance of 1.5 to 2.5 mm from the entry point. The polarized videoreflectometry of the skin may be a useful tool to assess skin fibrosis resulting from radiation treatment. © 2005 Society of Photo-Optical Instrumentation Engineers.

© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

Alexander Sviridov ; Victor Chernomordik ; Moinuddin Hassan ; Angelo Russo ; Alec Eidsath, et al.
"Intensity profiles of linearly polarized light backscattered from skin and tissue-like phantoms", J. Biomed. Opt. 10(1), 014012 (Feb. 10, 2005). ; http://dx.doi.org/10.1117/1.1854677


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