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Research Papers

In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy

[+] Author Affiliations
Jun Zhao, Hai Shu Ding

Tsinghua University, Department of Biomedical Engineering, Beijing 100084, China E-mail: dhs-dea@mail.tsinghua.edu.cn

Xin Lin Hou, Cong Le Zhou

First Hospital of Peking University, Department of Pediatrics, Beijing 100034, China

Britton Chance

University of Pennsylvania, Department of Biochemistry and Biophysics, Philadelphia, Pennsylvania 19104

J. Biomed. Opt. 10(2), 024028 (Jun. 1, 2004Sep. 30, 2004Oct. 11, 2004Apr. 4, 2005April 04, 2005). doi:10.1117/1.1891345
History: Received Jun. 1, 2004; Revised Sep. 30, 2004; Accepted Oct. 11, 2004; Apr. 4, 2005; Online April 04, 2005
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We investigate the optical properties of the brain in 23 neonates in vivo using a frequency domain near-infrared spectroscopy (NIRS). In this study, a calibration procedure is employed to determine the absorption and reduced scattering coefficients with single source-detector separation. The absorption coefficients of the infant foreheads are lower than the values reported in adults. A large intersubject variation in the reduced scattering coefficients is also demonstrated. Furthermore, physiological parameters are derived from the absorption coefficients at two wavelengths (788 and 832 nm). The mean total hemoglobin concentration (THC) is 39.7±9.8 μM and the mean cerebral blood oxygen saturation (StO2) is 58.7±11.2%. Our preliminary results show that this bedside frequent domain NIRS could provide quantitative optical measurement of the infant brain. © 2005 Society of Photo-Optical Instrumentation Engineers.

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© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

Jun Zhao ; Xin Lin Hou ; Britton Chance ; Cong Le Zhou and Hai Shu Ding
"In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy", J. Biomed. Opt. 10(2), 024028 (Jun. 1, 2004Sep. 30, 2004Oct. 11, 2004Apr. 4, 2005April 04, 2005). ; http://dx.doi.org/10.1117/1.1891345


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