0
Research Papers

Coregistered tomographic x-ray and optical breast imaging: initial results

[+] Author Affiliations
Quan Zhang

Harvard Medical School, Massachusetts General Hospital, The Martinos Center for Biomedical Imaging, 13th Street, Building 149, Room 2301, Charlestown, Massachusetts 02129 E-mail: qzhang@nmr.mgn.harvard.edu

Thomas J. Brukilacchio

Innovations in Optics, Inc., Woburn, Massachusetts 01801

Ang Li

Tufts University, Physics Dept, Medford, Massachusetts 02155

Jonathan J. Stott, Tina Chaves, Elizabeth Hillman

Harvard Medical School, Massachusetts General Hospital, The Martinos Center for Biomedical Imaging, 13th Street, Building 149, Room 2301, Charlestown, Massachusetts 02129

Tao Wu, MaryAnn Chorlton, Elizabeth Rafferty, Richard H. Moore, Daniel B. Kopans

Harvard Medical School, Massachusetts General Hospital, The Breast Imaging Unit, Boston, Massachusetts 02114

David A. Boas

Harvard Medical School, Massachusetts General Hospital, The Martinos Center for Biomedical Imaging, 13th Street, Building 149, Room 2301, Charlestown, Massachusetts 02129

J. Biomed. Opt. 10(2), 024033 (Apr. 13, 2005). doi:10.1117/1.1899183
History: Received Jun. 10, 2004; Revised Aug. 23, 2004; Accepted Sep. 9, 2004; Apr. 13, 2005; Online April 13, 2005
Text Size: A A A

We describe what is, to the best of our knowledge, the first pilot study of coregistered tomographic x-ray and optical breast imaging. The purpose of this pilot study is to develop both hardware and data processing algorithms for a multimodality imaging method that provides information that neither x-ray nor diffuse optical tomography (DOT) can provide alone. We present in detail the instrumentation and algorithms developed for this multimodality imaging. We also present results from our initial pilot clinical tests. These results demonstrate that strictly coregistered x-ray and optical images enable a detailed comparison of the two images. This comparison will ultimately lead to a better understanding of the relationship between the functional contrast afforded by optical imaging and the structural contrast provided by x-ray imaging. © 2005 Society of Photo-Optical Instrumentation Engineers.

Figures in this Article
© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

Quan Zhang ; Thomas J. Brukilacchio ; Ang Li ; Jonathan J. Stott ; Tao Wu, et al.
"Coregistered tomographic x-ray and optical breast imaging: initial results", J. Biomed. Opt. 10(2), 024033 (Apr. 13, 2005). ; http://dx.doi.org/10.1117/1.1899183


Access This Article
Sign In to Access Full Content
Please Wait... Processing your request... Please Wait.
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
 
Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content

Tables

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement

Buy this article ($18 for members, $25 for non-members).
Sign In