Special Section on Infrared and Raman Spectroscopy

Raman spectroscopy for noninvasive glucose measurements

[+] Author Affiliations
Annika M. K. Enejder

Chalmers University, Department of Experimental Physics, Goteborg, Sweden

Thomas G. Scecina

Massachusetts Institute of Technology, George R. Harrison Spectroscopy Laboratory, Cambridge, Massachusetts 02139

Jeankun Oh

Skymoon R&D, 3045 Park Boulevard Palo Alto, California 94306

Martin Hunter, Wei-Chuan Shih

Massachusetts Institute of Technology, George R. Harrison Spectroscopy Laboratory, Cambridge, Massachusetts 02139

Slobodan Sasic

Pfizer, Analytical R&D, Ramsgate Road Sandwich, CT 13 9NJ United Kingdom

Gary L. Horowitz

Beth Israel Deaconess Medical Center, Department of Pathology, Boston, Massachusetts 02215

Michael S. Feld

Massachusetts Institute of Technology, George R. Harrison Spectroscopy Laboratory, Cambridge, Massachusetts 02139

J. Biomed. Opt. 10(3), 031114 (Jun. 7, 2005). doi:10.1117/1.1920212
History: Received Sep. 10, 2004; Revised Dec. 18, 2004; Accepted Dec. 20, 2004; Jun. 7, 2005; Online June 07, 2005
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We report the first successful study of the use of Raman spectroscopy for quantitative, noninvasive (“transcutaneous”) measurement of blood analytes, using glucose as an example. As an initial evaluation of the ability of Raman spectroscopy to measure glucose transcutaneously, we studied 17 healthy human subjects whose blood glucose levels were elevated over a period of 2–3 h using a standard glucose tolerance test protocol. During the test, 461 Raman spectra were collected transcutaneously along with glucose reference values provided by standard capillary blood analysis. A partial least squares calibration was created from the data from each subject and validated using leave-one-out cross validation. The mean absolute errors for each subject were 7.8%±1.8% (mean±std) with R2 values of 0.83±0.10. We provide spectral evidence that the glucose spectrum is an important part of the calibrations by analysis of the calibration regression vectors. © 2005 Society of Photo-Optical Instrumentation Engineers.

© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

Annika M. K. Enejder ; Thomas G. Scecina ; Jeankun Oh ; Martin Hunter ; Wei-Chuan Shih, et al.
"Raman spectroscopy for noninvasive glucose measurements", J. Biomed. Opt. 10(3), 031114 (Jun. 7, 2005). ; http://dx.doi.org/10.1117/1.1920212


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