Research Papers

Bronchoscopic imaging of pulmonary mucosal vasculature responses to inflammatory mediators

[+] Author Affiliations
Melissa Suter

University of Iowa Hospitals and Clinics, Department of Internal Medicine, Iowa City, Iowa

University of Iowa, Department of Biomedical Engineering, Iowa City, Iowa

Joseph Reinhardt

University of Iowa, Department of Biomedical Engineering, Iowa City, Iowa

Paul Montague

University of Iowa Hospitals and Clinics, Department of Ophthalmology, Iowa City, Iowa

Peter Taft, John Lee, Joseph Zabner

University of Iowa Hospitals and Clinics, Department of Internal Medicine, Iowa City, Iowa

Geoffrey McLennanUniversity of Iowa Hospitals and Clinics, Department of Internal Medicine, Iowa City, Iowa

University of Iowa, Department of Biomedical Engineering, Iowa City, Iowa

J. Biomed. Opt. 10(3), 034013 (Jun. 14, 2005). doi:10.1117/1.1924714
History: Received Dec. 19, 2003; Revised Jun. 15, 2004; Accepted Dec. 20, 2004; Jun. 14, 2005; Online June 14, 2005
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In current clinical practice, the initial stage in the detection of pulmonary airway disease is the clinician’s interpretation of a bronchoscopy procedure. Due to the nature of this form of detection, diseases are often well advanced upon discovery. This paper proposes a new method for examining the pulmonary airway microcirculatory system via fluorescein imaging techniques similar to those used extensively in ophthalmology. Through the use of a specialized bronchoscopy imaging system we are able to successfully show that fluorescein emission detected in the rabbit trachea exhibits a clear response to inflammatory mediators and thus to changing local vascularity. The clinical implications of this technique are extensive including most importantly the potential use as an evaluation tool for pulmonary disease evaluation and likely other endoscopically accessible organs. © 2005 Society of Photo-Optical Instrumentation Engineers.

© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

Melissa Suter ; Joseph Reinhardt ; Paul Montague ; Peter Taft ; John Lee, et al.
"Bronchoscopic imaging of pulmonary mucosal vasculature responses to inflammatory mediators", J. Biomed. Opt. 10(3), 034013 (Jun. 14, 2005). ; http://dx.doi.org/10.1117/1.1924714


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