Research Papers

Intersubject variability of near-infrared spectroscopy signals during sensorimotor cortex activation

[+] Author Affiliations
Hiroki Sato

Hitachi, Limited, Advanced Research Laboratory, 2520 Akanuma, Hatoyama, Saitama 350-0395, Japan

Yutaka Fuchino

Kitasato University, Graduate School of Medical Sciences, 1-15-1 Kitasato Sagamihara, Kanagawa 228-8555, Japan

Masashi Kiguchi, Takusige Katura, Atsushi Maki

Hitachi, Limited, Advanced Research Laboratory, 2520 Akanuma, Hatoyama, Saitama 350-0395, Japan

Takeshi Yoro

Kitasato University, Graduate School of Medical Sciences, 1-15-1 Kitasato Sagamihara, Kanagawa 228-8555, Japan

Hideaki Koizumi

Hitachi, Limited, Advanced Research Laboratory, 2520 Akanuma, Hatoyama, Saitama 350-0395, Japan

J. Biomed. Opt. 10(4), 044001 (July 15, 2005). doi:10.1117/1.1960907
History: Received June 22, 2004; Revised February 07, 2005; Accepted February 14, 2005; Published July 15, 2005
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We investigate the intersubject signal variability of near-infrared spectroscopy (NIRS), which is commonly used for noninvasive measurement of the product of the optical path length and the concentration change in oxygenated hemoglobin (ΔCoxy) and deoxygenated hemoglobin (ΔCdeoxy) and their sum (ΔCtotal) related to human cortical activation. We do this by measuring sensorimotor cortex activation in 31 healthy adults using 24-measurement-position near-infrared (NIR) topography. A finger-tapping task is used to activate the sensorimotor cortex, and significant changes in the hemisphere contralateral to the tapping hand are assessed as being due to the activation. Of the possible patterns of signal changes, 90% include a positive ΔCoxy, 76% included a negative ΔCdeoxy, and 73% included a positive ΔCtotal. The ΔCdeoxy and ΔCtotal are less consistent because of a large intersubject variability in ΔCdeoxy; in some cases there is a positive ΔCdeoxy. In the cases with no positive ΔCoxy in the contralateral hemisphere, there are cases of other possible changes for either or both hemispheres and no cases of no change in any hemoglobin species in either hemisphere. These results suggest that NIR topography is useful for observing brain activity in most cases, although intersubject signal variability still needs to be resolved.

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© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

Hiroki Sato ; Yutaka Fuchino ; Masashi Kiguchi ; Takusige Katura ; Atsushi Maki, et al.
"Intersubject variability of near-infrared spectroscopy signals during sensorimotor cortex activation", J. Biomed. Opt. 10(4), 044001 (July 15, 2005). ; http://dx.doi.org/10.1117/1.1960907


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