Research Papers

Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy

[+] Author Affiliations
Jun Li

Universität Konstanz, Fachbereich Physik and Fachbereich Psychologie, Universitätsstr. 10, 78457 Konstanz, Germany

Gregor Dietsche

Universität Konstanz, Fachbereich Physik, 78457 Konstanz, Germany

Diana Iftime

Universität Konstanz, Fachbereich Psychologie, 78457 Konstanz, Germany

Sergey E. Skipetrov

Université Joseph Fourier, Laboratoire de Physique et Modélisation des Milieux Condensés, CNRS, 38042 Grenoble, France

Georg Maret

Universität Konstanz, Fachbereich Physik, 78457 Konstanz, Germany

Thomas Elbert, Brigitte Rockstroh

Universität Konstanz, Fachbereich Psychologie, 78457 Konstanz, Germany

Thomas Gisler

Universität Konstanz, Fachbereich Physik, 78457 Konstanz, Germany

J. Biomed. Opt. 10(4), 044002 (August 23, 2005). doi:10.1117/1.2007987
History: Received August 19, 2004; Revised April 04, 2005; Accepted April 05, 2005; Published August 23, 2005
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We use near-infrared dynamic multiple scattering of light [diffusing-wave spectroscopy (DWS)] to detect the activation of the somato-motor cortex in 11 right-handed volunteers performing a finger opposition task separately with their right and left hands. Temporal autocorrelation functions g(1)(r,τ) of the scattered light field are measured during 100-s periods of motor task alternating with 100-s resting baseline periods. From an analysis of the experimental data with an analytical theory for g(1)(r,τ) from a three-layer geometry with optical and dynamical heterogeneity representing scalp, skull, and cortex, we obtain quantitative estimates of the diffusion coefficient in cortical regions. Consistent with earlier results, the measured cortical diffusion coefficient is found to be increased during the motor task, with a strong contralateral and a weaker ipsilateral increase consistent with the known brain hemispheric asymmetry for right-handed subjects. Our results support the interpretation of the increase of the cortical diffusion coefficient during finger opposition being due to the functional increase in cortical blood flow rate related to vasodilation.

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© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

Jun Li ; Gregor Dietsche ; Diana Iftime ; Sergey E. Skipetrov ; Georg Maret, et al.
"Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy", J. Biomed. Opt. 10(4), 044002 (August 23, 2005). ; http://dx.doi.org/10.1117/1.2007987


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