Research Papers

Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models

[+] Author Affiliations
Daqing Piao

University of Connecticut, Electrical and Computer Engineering Department, Storrs, Connecticut 06269

Mehran M. Sadeghi, Jiasheng Zhang

Yale University School of Medicine, and VA Connecticut Healthcare System, Department of Internal Medicine, New Haven, Connecticut 06510

Yueli Chen

University of Connecticut, Electrical and Computer Engineering Department, Storrs, Connecticut 06269

Albert J. Sinusas

Yale University School of Medicine, Department of Internal Medicine, Diagnostic Radiology, New Haven, Connecticut 06510

Quing Zhu

University of Connecticut, Electrical and Computer Engineering Department, Storrs, Connecticut 06269

J. Biomed. Opt. 10(4), 044010 (July 15, 2005). doi:10.1117/1.1954773
History: Received July 15, 2004; Revised February 14, 2005; Accepted February 28, 2005; Published July 15, 2005
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We evaluate the performance of our novel hybrid optical coherence tomography (OCT) and scintillating probe, demonstrate simultaneous OCT imaging and scintillating detection, and validate the system using an atherosclerotic rabbit model. Preliminary data obtained from the rabbit model suggest that our prototype positron probe detects local uptake of fluorodeoxyglucose (FDG) labeled with F18 positron (beta) radionuclide emitter, and the high-uptake regions correlate with sites of injury and extensive atherosclerosis areas. Preliminary data also suggest that coregistered high-resolution OCT images provide imaging of detailed plaque microstructures, which cannot be resolved by positron detection.

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© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

Daqing Piao ; Mehran M. Sadeghi ; Jiasheng Zhang ; Yueli Chen ; Albert J. Sinusas, et al.
"Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models", J. Biomed. Opt. 10(4), 044010 (July 15, 2005). ; http://dx.doi.org/10.1117/1.1954773


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