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Research Papers

Depth-sensitive reflectance measurements using obliquely oriented fiber probes

[+] Author Affiliations
Adrien Ming Jer Wang, Janelle Elise Bender

Rice University, Department of Bioengineering, Houston, Texas

Joshua Pfefer

Food and Drug Administration, Center for Devices and Radiological Health, Rockville, Maryland

Urs Utzinger

University of Arizona, Biomedical Engineering Program and OB/GYN, Tucson, Arizona

Rebekah Anna Drezek

Rice University, Department of Bioengineering, Houston, Texas

J. Biomed. Opt. 10(4), 044017 (August 01, 2005). doi:10.1117/1.1989335
History: Received July 29, 2004; Revised March 16, 2005; Accepted March 17, 2005; Published August 01, 2005
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Computer simulation is used to facilitate the design of fiber-probe geometries that enable enhanced detection of optical signals arising from specific tissue depths. Obtaining understanding of the relationship between fiber-probe design and tissue interrogation is critical when developing strategies for optical detection of epithelial precancers that originate at known depths from the tissue surface. The accuracy of spectroscopic diagnostics may be enhanced by discretely probing the optical properties of epithelium and underlying stroma, within which the morphological and biochemical features vary as a function of depth. While previous studies have investigated controlling tissue-probing depth for fluorescence-based modalities, in this study we focus on the detection of reflected light scattered by tissue. We investigate how the depth of optical interrogation may be controlled through combinations of collection angles, source-detector separations, and numerical apertures. We find that increasing the obliquity of collection fibers at a given source-detector separation can effectively enhance the detection of superficially scattered signals. Fiber numerical aperture provides additional depth selectivity; however, the perturbations in sampling depth achieved through this means are modest relative to the changes generated by modifying the angle of collection and source-detection separation.

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© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

Adrien Ming Jer Wang ; Janelle Elise Bender ; Joshua Pfefer ; Urs Utzinger and Rebekah Anna Drezek
"Depth-sensitive reflectance measurements using obliquely oriented fiber probes", J. Biomed. Opt. 10(4), 044017 (August 01, 2005). ; http://dx.doi.org/10.1117/1.1989335


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