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Research Papers

Design, fabrication, and characterization of a tissue-equivalent phantom for optical elastography

[+] Author Affiliations
C. Usha Devi, R. M. Vasu

Indian Institute of Science, Department of Instrumentation, Bangalore-560 012, India

A. K. Sood

Indian Institute of Science, Department of Physics, Bangalore-560 012, India

J. Biomed. Opt. 10(4), 044020 (August 01, 2005). doi:10.1117/1.2003833
History: Received October 14, 2004; Revised April 01, 2005; Accepted April 25, 2005; Published August 01, 2005
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We suitably adapt the design of a tissue-equivalent phantom used for photoacoustic imaging to construct phantoms for optical elastography. The elastography phantom we consider should have optical properties such as scattering coefficient, scattering anisotropy factor, and refractive index; mechanical properties such as storage and loss modulus; and acoustic properties such as ultrasound velocity, attenuation coefficient, and acoustic impedance to match healthy and diseased tissues. The phantom is made of poly (vinyl alcohol) (PVA) and its mechanical, optical, and acoustic properties are tailored by physical cross-linking effected through subjecting a suitable mix of PVA stock and water to a number of freeze-thaw cycles and by varying the degree of hydrolysis in the PVA stock. The optical, mechanical, and acoustic properties of the samples prepared are measured by employing different techniques. The measured variations in the values of optical scattering coefficient, scattering anisotropy factor, and refractive index and storage modulus are found to be comparable to those in normal and diseased breast tissues. The acoustic properties such as sound speed, acoustic attenuation coefficient, and density are found to be close to the average values reported in the literature for normal breast tissue.

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© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

C. Usha Devi ; R. M. Vasu and A. K. Sood
"Design, fabrication, and characterization of a tissue-equivalent phantom for optical elastography", J. Biomed. Opt. 10(4), 044020 (August 01, 2005). ; http://dx.doi.org/10.1117/1.2003833


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