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JBO Letters

Contrast-detail analysis characterizing diffuse optical fluorescence tomography image reconstruction

[+] Author Affiliations
Scott C. Davis, Brian W. Pogue, Hamid Dehghani, Keith D. Paulsen

Dartmouth College, Thayer School of Engineering, Hanover New Hampshire 03755

J. Biomed. Opt. 10(5), 050501 (October 31, 2005). doi:10.1117/1.2114727
History: Received May 05, 2005; Revised August 23, 2005; Accepted September 14, 2005; Published October 31, 2005
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Abstract

Contrast-detail analysis is used to evaluate the imaging performance of diffuse optical fluorescence tomography (DOFT), characterizing spatial resolution limits, signal-to-noise limits, and the trade-off between object contrast and size. Reconstructed images of fluorescence yield from simulated noisy data were used to determine the contrast-to-noise ratio (CNR). A threshold of CNR=3 was used to approximate a lowest acceptable noise level in the image, as a surrogate measure for human detection of objects. For objects 0.5cm inside the edge of a simulated tissue region, the smallest diameter that met this criteria was approximately 1.7mm, regardless of contrast level, and test field diameter had little impact on this limit. Object depth had substantial impact on object CNR, leading to a limit of 4mm for objects near the center of a 51-mm test field and 8.5mm for an 86-mm test field. Similarly, large objects near the edge of both test fields required a minimum contrast of 50% to achieve acceptable image CNR. The minimum contrast for large, centered objects ranged between 50% and 100%. Contrast-detail analysis using human detection of lower contrast limits provides fundamentally important information about the performance of reconstruction algorithms, and can be used to compare imaging performance of different systems.

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© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

Scott C. Davis ; Brian W. Pogue ; Hamid Dehghani and Keith D. Paulsen
"Contrast-detail analysis characterizing diffuse optical fluorescence tomography image reconstruction", J. Biomed. Opt. 10(5), 050501 (October 31, 2005). ; http://dx.doi.org/10.1117/1.2114727


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