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Special Section on Optical Diagnostic Imaging from Bench to Bedside Spectroscopy

Toward the clinical application of time-domain fluorescence lifetime imaging

[+] Author Affiliations
N. Galletly

Imperial College London, Department of Histopathology, Division of Investigative Sciences, Hammersmith Campus, Du Cane Road, London W12 ONN

J. Requejo-Isidro, P. M. P. Lanigan, D. S. Elson, C. Dunsby, M. A. A. Neil

Imperial College London, Physics Department, Photonics Group, South Kensington Campus, London SW7 2AZ

I. Munro, J. McGinty

Imperial College London, Physics Department, Photonics Group, South Kensington Campus, London SW7 2AZ

M. J. Lever

Imperial College London, Bioengineering Department, Photonics Group, South Kensington Campus, London SW7 2AZ

G. W. H. Stamp

Imperial College London, Department of Histopathology, Division of Investigative Sciences, Hammersmith Campus, Du Cane Road, London W12 ONN

P. M. W. French

Imperial College London, Physics Department, Photonics Group, South Kensington Campus, London SW7 2AZ

J. Biomed. Opt. 10(5), 051403 (October 31, 2005). doi:10.1117/1.2102807
History: Received February 18, 2005; Revised May 20, 2005; Accepted June 10, 2005; Published October 31, 2005
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High-speed (video-rate) fluorescence lifetime imaging (FLIM) through a flexible endoscope is reported based on gated optical image intensifier technology. The optimization and potential application of FLIM to tissue autofluorescence for clinical applications are discussed.

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© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

N. Galletly ; J. Requejo-Isidro ; I. Munro ; M. J. Lever ; G. W. H. Stamp, et al.
"Toward the clinical application of time-domain fluorescence lifetime imaging", J. Biomed. Opt. 10(5), 051403 (October 31, 2005). ; http://dx.doi.org/10.1117/1.2102807


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