Special Section on Optical Diagnostic Imaging from Bench to Bedside Image and Parameters Analysis

Optical imaging of turbid media using independent component analysis: theory and simulation

[+] Author Affiliations
M. Xu, M. Alrubaiee, S. K. Gayen, R. R. Alfano

The City College and Graduate Center of the City University of New York, Department of Physics, Institute for Ultrafast Spectroscopy and Lasers, , New York, New York 10031

J. Biomed. Opt. 10(5), 051705 (October 24, 2005). doi:10.1117/1.2101568
History: Received December 07, 2004; Revised February 25, 2005; Accepted March 14, 2005; Published October 24, 2005
Text Size: A A A

A new imaging approach for 3-D localization and characterization of objects in a turbid medium using independent component analysis (ICA) from information theory is developed and demonstrated using simulated data. This approach uses a multisource and multidetector signal acquisition scheme. ICA of the perturbations in the spatial intensity distribution measured on the medium boundary sorts out the embedded objects. The locations and optical characteristics of the embedded objects are obtained from a Green’s function analysis based on any appropriate model for light propagation in the background medium. This approach is shown to locate and characterize absorptive and scattering inhomogeneities within highly scattering medium to a high degree of accuracy. In particular, we show this approach can discriminate between absorptive and scattering inhomogeneities, and can locate and characterize complex inhomogeneities, which are both absorptive and scattering. The influence of noise and uncertainty in background absorption or scattering on the performance of this approach is investigated.

Figures in this Article
© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

M. Xu ; M. Alrubaiee ; S. K. Gayen and R. R. Alfano
"Optical imaging of turbid media using independent component analysis: theory and simulation", J. Biomed. Opt. 10(5), 051705 (October 24, 2005). ; http://dx.doi.org/10.1117/1.2101568


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.