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Special Section on Optical Diagnostic Imaging from Bench to Bedside Image and Parameters Analysis

Enhancement of hidden structures of early skin fibrosis using polarization degree patterns and Pearson correlation analysis

[+] Author Affiliations
Alexander P. Sviridov

National Institutes of Health, Bethesda, Maryland 20892, and , Institute for Laser and Information Technologies, of Russian Academy of Sciences, Troitsk, Moscow Region, 142190, Russia

Victor Chernomordik, Moinuddin Hassan

National Institutes of Health, Bethesda, Maryland 20892

Albert C. Boccara

Ecole Superinieure de Physique et de Chimie , Industrielle de Paris (ESPCI), 10 Rue Vauquelin, Paris 75005, France

Angelo Russo, Paul Smith, Amir Gandjbakhche

National Institutes of Health, Bethesda, Maryland 20892

J. Biomed. Opt. 10(5), 051706 (October 04, 2005). doi:10.1117/1.2073727
History: Received December 22, 2004; Revised May 04, 2005; Accepted May 06, 2005; Published October 04, 2005
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The skin of athymic nude mice is irradiated with a single dose of x-ray irradiation that initiated fibrosis. Digital photographs of the irradiated mice are taken by illuminating the mouse skin with linearly polarized probe light of 650nm. The specific pattern of the surface distribution of the degree of polarization enables the detection of initial skin fibrosis structures that were not visually apparent. Data processing of the raw spatial distributions of the degree of polarization based on Fourier filtering of the high-frequency noise improves subjective perception of the revealed structure in the images. In addition, Pearson correlation analysis provides information about skin structural size and directionality.

Figures in this Article
© 2005 Society of Photo-Optical Instrumentation Engineers

Topics

Polarization ; Skin

Citation

Alexander P. Sviridov ; Victor Chernomordik ; Moinuddin Hassan ; Albert C. Boccara ; Angelo Russo, et al.
"Enhancement of hidden structures of early skin fibrosis using polarization degree patterns and Pearson correlation analysis", J. Biomed. Opt. 10(5), 051706 (October 04, 2005). ; http://dx.doi.org/10.1117/1.2073727


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