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Research Papers

Near-infrared fiber optic spectroscopy as a novel diagnostic tool for the detection of pancreatic cancer

[+] Author Affiliations
Venkata R. Kondepati, Johann Zimmermann

Mannheim University of Applied Sciences, Institute for Instrumental Analysis and Bioanalysis, Mannheim, Germany

Michael Keese, Joerg Sturm, Bernd C. Manegold

University of Heidelberg, Faculty for Clinical Medicine, Surgical Clinic, Mannheim, Germany

Juergen Backhaus

Mannheim University of Applied Sciences, Institute for Instrumental Analysis and Bioanalysis, Mannheim, Germany

J. Biomed. Opt. 10(5), 054016 (October 13, 2005). doi:10.1117/1.2060568
History: Received December 14, 2004; Revised May 11, 2005; Accepted May 23, 2005; Published October 13, 2005
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We have investigated the application of near-infrared (NIR) fiber-optic spectroscopy for the diagnosis of pancreatic cancer. Cluster analysis of the Fourier transformed near-infrared (FTNIR) fiber-optic spectra of surgically resected pancreatic tumor tissues allowed discrimination of tumor from normal tissue with high sensitivity and specificity. The sensitivity of the method using spectral information of the CH stretching first overtone region (59515608cm1) was 83.3% with a specificity of 83.3%. Based on the CH stretching second overtone region (86057938cm1) we could achieve a sensitivity of 88.9% and specificity of 72.2%. These findings suggest that NIR spectroscopy offers the potential for minimally invasive in-vivo diagnosis of pancreatic cancer.

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© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

Venkata R. Kondepati ; Johann Zimmermann ; Michael Keese ; Joerg Sturm ; Bernd C. Manegold, et al.
"Near-infrared fiber optic spectroscopy as a novel diagnostic tool for the detection of pancreatic cancer", J. Biomed. Opt. 10(5), 054016 (October 13, 2005). ; http://dx.doi.org/10.1117/1.2060568


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