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Research Papers

Effect of errors in baseline optical properties on accuracy of transabdominal near-infrared spectroscopy in fetal sheep brain during hypoxic stress

[+] Author Affiliations
Theresa Mawn

University of Pennsylvania, Department of Bioengineering, Philadelphia, Pennsylvania 19104-6100

Shoko Nioka

University of Pennsylvania, Department of Biochemistry and Biophysics, Philadelphia, Pennsylvania 19104-6100

Mark Nijland

Cornell University, Department of Biomedical Sciences, Ithaca, New York 14853-6401

Luke Bloy, Mark A. Elliott

University of Pennsylvania, Department of Radiology, Philadelphia, Pennsylvania 19104-6100

Britton Chance

University of Pennsylvania, Department of Biochemistry and Biophysics, Philadelphia, Pennsylvania 19104-6100

John S. Leigh

University of Pennsylvania, Department of Radiology, Philadelphia, Pennsylvania 19104-6100

J. Biomed. Opt. 10(6), 064001 (November 02, 2005). doi:10.1117/1.2118730
History: Received September 28, 2004; Revised April 12, 2005; Revised June 01, 2005; Accepted June 03, 2005; Published November 02, 2005
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A continuous-wave (cw) near-infrared spectroscopy (NIRS) instrument has been developed to noninvasively quantify fetal cerebral blood oxygen saturation (StO2). A linear Green’s function formulism was used to analytically solve the photon diffusion equation and extract the time-varying fetal tissue oxy- and deoxy-hemoglobin concentrations from the NIR measurements. Here we explored the accuracy with which this instrument can be expected to perform over a range of fetal hypoxic states. We investigated the dependence of this accuracy on the accuracy of the reference optical properties chosen based on the literature. The fetal oxygenation of a pregnant ewe model was altered via maternal aortic occlusion. The NIR cw instrument was placed on the maternal abdomen directly above the fetal head, continuously acquiring diffuse optical measurements. Blood was sampled periodically from the fetus to obtain fetal arterial saturation (SaO2) measurements from blood gas analysis. The NIR StO2 values were compared with the fetal SaO2 measurements. Variations in the NIR results due to uncertainty in the reference optical properties were relatively small within the fetal SaO2 range of 30 to 80%. Under hypoxic conditions, however, the variability of the NIR StO2 calculations with changes in the assumed reference properties became more significant.

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© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

Theresa Mawn ; Shoko Nioka ; Mark Nijland ; Luke Bloy ; Britton Chance, et al.
"Effect of errors in baseline optical properties on accuracy of transabdominal near-infrared spectroscopy in fetal sheep brain during hypoxic stress", J. Biomed. Opt. 10(6), 064001 (November 02, 2005). ; http://dx.doi.org/10.1117/1.2118730


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