Research Papers

Toward the discrimination of early melanoma from common and dysplastic nevus using fiber optic diffuse reflectance spectroscopy

[+] Author Affiliations
Bruce W. Murphy, Rebecca J. Webster

The University of Western Australia, School of Electrical, Electronic, and Computer Engineering, Optical+Biomedical Engineering Laboratory, M018, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Berwin A. Turlach

The University of Western Australia, School of Mathematics and Statistics, M019, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Christopher J. Quirk, Christopher D. Clay

Royal Perth Hospital, Department of Dermatology, Perth, Western Australia 6000, Australia

Peter J. Heenan

Cutaneous Pathology, 26 Leura Street, Nedlands, Western Australia 6009, Australia

David D. Sampson

The University of Western Australia, School of Electrical, Electronic, and Computer Engineering, Optical+Biomedical Engineering Laboratory, M018, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

J. Biomed. Opt. 10(6), 064020 (November 18, 2005). doi:10.1117/1.2135799
History: Received March 29, 2005; Revised June 17, 2005; Accepted June 17, 2005; Published November 18, 2005
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We describe a study of the discrimination of early melanoma from common and dysplastic nevus using fiber optic diffuse reflectance spectroscopy. Diffuse reflectance spectra in the wavelength range 550to1000nm are obtained using 400-μm core multimode fibers arranged in a six-illumination-around-one-collection geometry with a single fiber-fiber spacing of 470μm. Spectra are collected at specific locations on 120 pigmented lesions selected by clinicians as possible melanoma, including 64 histopathologically diagnosed as melanoma. These locations are carried through to the histopathological diagnosis, permitting a spatially localized comparison with the corresponding spectrum. The variations in spectra between groups of lesions with different diagnoses are examined and reduced to features suitable for discriminant analysis. A classifier distinguishing between benign and malignant lesions performs with sensitivity/specificity of between 6469% and 7278%. Classifiers between pairs of the group common nevus, dysplastic nevus, in situ melanoma, and invasive melanoma show better or similar performance than the benign/malignant classifier, and analysis provides evidence that different spectral features are needed for each pair of groups. This indicates that multiple discriminant systems are likely to be required to distinguish between melanoma and similar lesions.

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© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

Bruce W. Murphy ; Rebecca J. Webster ; Berwin A. Turlach ; Christopher J. Quirk ; Christopher D. Clay, et al.
"Toward the discrimination of early melanoma from common and dysplastic nevus using fiber optic diffuse reflectance spectroscopy", J. Biomed. Opt. 10(6), 064020 (November 18, 2005). ; http://dx.doi.org/10.1117/1.2135799


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