Research Papers

Simulating the response of terahertz radiation to basal cell carcinoma using ex vivo spectroscopy measurements

[+] Author Affiliations
Emma Pickwell

Cambridge University, Cavendish Laboratory, Semiconductor Physics Group, Madingley Road, Cambridge CB3 0HE, United Kingdom and TeraView Limited, Platinum Building, St. John’s Innovation Park, Cambridge CB4 0WS, United Kingdom

Anthony J. Fitzgerald, Bryan E. Cole, Philip F. Taday

TeraView, Limited, Platinum Building, St. John’s Innovation Park, Cambridge CB4 0WS, United Kingdom

Richard J. Pye, Thomas Ha

Addenbrooke’s Hospital, Department of Dermatology, Cambridge CB2 2QQ, United Kingdom

Michael Pepper

Cambridge University, Cavendish Laboratory, Semiconductor Physics Group, Madingley Road, Cambridge CB3 0HE, United Kingdom and TeraView Limited, Platinum Building, St. John’s Innovation Park, Cambridge CB4 0WS, United Kingdom

Vincent P. Wallace

TeraView, Limited, Platinum Building, St. John’s Innovation Park, Cambridge CB4 0WS, United Kingdom

J. Biomed. Opt. 10(6), 064021 (December 08, 2005). doi:10.1117/1.2137667
History: Received February 02, 2005; Revised June 10, 2005; Accepted June 27, 2005; Published December 08, 2005
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Studies of basal cell carcinoma using terahertz pulsed imaging have revealed a significant difference between regions of tumor and healthy tissue. These differences are manifested in the reflected pulse due to what is thought to be changes in refractive index and absorption. We present measurements of the refractive index and absorption coefficient of excised normal tissue and basal cell carcinoma using terahertz (THz) transmission spectroscopy. We extract Debye parameters from these data and enter them into a finite difference time domain simulation to predict the shape of the waveforms reflected off the normal tissue and basal cell carcinoma and compare them with published in vivo data. Simulating the interaction of terahertz radiation with normal and cancerous tissue is a key step toward understanding the origin of contrast in terahertz images of skin cancer.

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© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

Emma Pickwell ; Anthony J. Fitzgerald ; Bryan E. Cole ; Philip F. Taday ; Richard J. Pye, et al.
"Simulating the response of terahertz radiation to basal cell carcinoma using ex vivo spectroscopy measurements", J. Biomed. Opt. 10(6), 064021 (December 08, 2005). ; http://dx.doi.org/10.1117/1.2137667


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